GNA15 and OPRK1

Number of citations of the paper that reports this interaction (PubMedID 9572309)
11

Data Source:
HPRD (in vivo)

		GNA15	OPRK1
Description		G protein subunit alpha 15	opioid receptor kappa 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Heterotrimeric G-protein Complex Plasma Membrane Synapse	Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Synapse
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Dynorphin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway	Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Opioid Receptor Signaling Pathway Regulation Of Saliva Secretion Defense Response To Virus
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Pethidine Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Menthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine 3-Methylthiofentanyl Heroin Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Ketobemidone Methylnaltrexone Eluxadoline Propoxyphene napsylate Naldemedine
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Heart failure ( 20445134)	IgE levels in asthmatics (D.p. specific) ( 23967269) Modic changes ( 30808802)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	5 interacting genes: GABARAPL1 GNA15 GPRASP1 OPRD1 SLC9A3R1
Entrez ID		2769	4986
HPRD ID		00760	01309
Ensembl ID		ENSG00000060558	ENSG00000082556
Uniprot IDs		P30679	A0A5F9ZI09 P41145
PDB IDs			2A0D 2IQN 4DJH 6B73
Enriched GO Terms of Interacting Partners?
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