SEC61G and SFTPC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SEC61G	SFTPC
Description		SEC61 translocon subunit gamma	surfactant protein C
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Multivesicular Body Lumen
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity	Protein Binding Identical Protein Binding
	Biological Process	Protein Targeting To ER Protein Transmembrane Transport	Respiratory Gaseous Exchange Cellular Protein Metabolic Process
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Surfactant metabolism Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Drugs
Diseases			Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Metabolite levels ( 23823483) Systemic lupus erythematosus ( 24871463) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)
Interacting Genes		3 interacting genes: CREB3 SEC61A1 SFTPC	12 interacting genes: CREB3 CXCL9 LMNA NEDD4 PQBP1 SEC22A SEC61G SMIM3 SYNE4 TMEM79 WWP1 WWP2
Entrez ID		23480	6440
HPRD ID		15318	01520
Ensembl ID		ENSG00000132432	ENSG00000168484
Uniprot IDs		A0A024QYZ0 P60059	A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686
PDB IDs			2YAD
Enriched GO Terms of Interacting Partners?
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