ATP13A2 and SEC61B

Number of citations of the paper that reports this interaction (PubMedID 22645275)
27

Data Source:
BioGRID (two hybrid)

		ATP13A2	SEC61B
Description		ATPase cation transporting 13A2	SEC61 translocon subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Lysosome Lysosomal Membrane Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Integral Component Of Membrane Transport Vesicle Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen Integral Component Of Lysosomal Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex
	Molecular Function	Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Cation-transporting ATPase Activity Manganese Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Cupric Ion Binding	RNA Binding ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Epidermal Growth Factor Binding
	Biological Process	Cellular Calcium Ion Homeostasis Cellular Iron Ion Homeostasis Cellular Zinc Ion Homeostasis Autophagy Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Cellular Cation Homeostasis Regulation Of Intracellular Protein Transport Ion Transmembrane Transport Cellular Response To Oxidative Stress Protein Autophosphorylation Positive Regulation Of Protein Secretion Regulation Of Endopeptidase Activity Zinc Ion Homeostasis Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process Peptidyl-aspartic Acid Autophosphorylation Regulation Of Ubiquitin-specific Protease Activity	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation
Pathways		Ion transport by P-type ATPases	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 25429064 31562340 20189936) Hip circumference adjusted for BMI ( 28552196 25673412) Intraocular pressure ( 29617998) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196)	Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	11 interacting genes: APOB ARL6 ATP13A2 BAG6 GET3 GET4 SEC63 SERP1 SPC25 TRAM1 UBL4A
Entrez ID		23400	10952
HPRD ID		13677	06715
Ensembl ID		ENSG00000159363	ENSG00000106803
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	P60468
PDB IDs
Enriched GO Terms of Interacting Partners?
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