ATP13A2 and CCKBR

Number of citations of the paper that reports this interaction (PubMedID 22645275)
27

Data Source:
BioGRID (two hybrid)

		ATP13A2	CCKBR
Description		ATPase cation transporting 13A2	cholecystokinin B receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cell Lysosome Lysosomal Membrane Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Integral Component Of Membrane Transport Vesicle Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen Integral Component Of Lysosomal Membrane	Cell Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Cation-transporting ATPase Activity Manganese Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Cupric Ion Binding	Cholecystokinin Receptor Activity Protein Binding Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Cellular Calcium Ion Homeostasis Cellular Iron Ion Homeostasis Cellular Zinc Ion Homeostasis Autophagy Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Cellular Cation Homeostasis Regulation Of Intracellular Protein Transport Ion Transmembrane Transport Cellular Response To Oxidative Stress Protein Autophosphorylation Positive Regulation Of Protein Secretion Regulation Of Endopeptidase Activity Zinc Ion Homeostasis Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process Peptidyl-aspartic Acid Autophosphorylation Regulation Of Ubiquitin-specific Protease Activity	Gastric Acid Secretion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Cholecystokinin Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity PH Reduction Digestive Tract Development Gland Development
Pathways		Ion transport by P-type ATPases	Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Pentagastrin
Diseases		Parkinson's disease (PD)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 25429064 31562340 20189936) Hip circumference adjusted for BMI ( 28552196 25673412) Intraocular pressure ( 29617998) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196)	Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	7 interacting genes: ADRB2 ATP13A2 CCK CCKAR NTM PPP1R9B PTPN11
Entrez ID		23400	887
HPRD ID		13677	00323
Ensembl ID		ENSG00000159363	ENSG00000110148
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	E9PIC8 P32239
PDB IDs			1L4T
Enriched GO Terms of Interacting Partners?
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