FLT3LG and PFN2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		FLT3LG	PFN2
Description		fms related receptor tyrosine kinase 3 ligand	profilin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Membrane Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Cytokine Activity Receptor Tyrosine Kinase Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Lymphocyte Differentiation Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Embryonic Hemopoiesis Positive Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Positive Regulation Of Osteoclast Proliferation Positive Regulation Of Myoblast Fusion	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling FLT3 Signaling STAT5 Activation	Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane
Diseases
GWAS		Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		3 interacting genes: FLT3 KITLG PFN2	32 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		2323	5217
HPRD ID		02477	01451
Ensembl ID		ENSG00000090554	ENSG00000070087
Uniprot IDs		B7ZLY4 M0QYM9 P49771	P35080
PDB IDs		1ETE 3QS7 3QS9	1D1J
Enriched GO Terms of Interacting Partners?
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