FLT3LG and KITLG

Number of citations of the paper that reports this interaction (PubMedID 25241761)
10

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		FLT3LG	KITLG
Description		fms related receptor tyrosine kinase 3 ligand	KIT ligand
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Membrane Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane Lamellipodium Filopodium
	Molecular Function	Signaling Receptor Binding Cytokine Activity Receptor Tyrosine Kinase Binding	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Lymphocyte Differentiation Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Embryonic Hemopoiesis Positive Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Positive Regulation Of Osteoclast Proliferation Positive Regulation Of Myoblast Fusion	MAPK Cascade Ovarian Follicle Development Neural Crest Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Positive Regulation Of Cell Proliferation Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling FLT3 Signaling STAT5 Activation
Drugs
Diseases			Familial progressive hyperpigmentation
GWAS		Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240)
Interacting Genes		3 interacting genes: FLT3 KITLG PFN2	8 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1
Entrez ID		2323	4254
HPRD ID		02477	01698
Ensembl ID		ENSG00000090554	ENSG00000049130
Uniprot IDs		B7ZLY4 M0QYM9 P49771	A0A024RBC0 A0A024RBF5 P21583
PDB IDs		1ETE 3QS7 3QS9	1EXZ 1SCF 2E9W
Enriched GO Terms of Interacting Partners?
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