DKK1 and KRTAP10-1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DKK1	KRTAP10-1
Description		dickkopf WNT signaling pathway inhibitor 1	keratin associated protein 10-1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Cytosol Keratin Filament
	Molecular Function	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Learning Or Memory Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Binding Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Synaptic Transmission, Glutamatergic Limb Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Motor Learning Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Modulation Of Age-related Behavioral Decline Synapse Pruning Positive Regulation Of Neuron Death Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Tau-protein Kinase Activity Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Cardiac Muscle Cell Differentiation	Keratinization
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	Keratinization
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 27577874 21076409 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	75 interacting genes: ADAMTSL4 AEN AMMECR1 AVPI1 BAHD1 BCL6B CARD9 CATSPER1 CBX2 CHIC2 CHRD CREB5 CXCL16 DAAM2 DHX57 DKK1 DOCK2 ECE1 FAM76B GLRX3 HOXA1 HPCAL1 HSD3B7 KRTAP10-3 KRTAP12-1 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E MAPKBP1 MEOX2 MOBP NECTIN2 NOTCH2NLA NPDC1 NR4A1 OTX1 PID1 PIN1 POM121L8P PRM2 PRPF31 RSPO2 SHFL SLC23A1 SLC6A20 SPATA8 SPRY1 SPRY2 TULP3 WT1 ZBTB24 ZNF101 ZNF124 ZNF264 ZNF286A ZNF329 ZNF417 ZNF433 ZNF439 ZNF440 ZNF559 ZNF572 ZNF581 ZNF587 ZNF785 ZSCAN12 ZSCAN26
Entrez ID		22943	386677
HPRD ID		05544	11184
Ensembl ID		ENSG00000107984	ENSG00000215455
Uniprot IDs		I1W660 O94907	P60331
PDB IDs		3S2K 3S8V 3SOQ 5FWW 5GJE
Enriched GO Terms of Interacting Partners?
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