KRTAP10-1 and HSD3B7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KRTAP10-1	HSD3B7
Description		keratin associated protein 10-1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function		3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
	Biological Process	Keratinization	Bile Acid Biosynthetic Process B Cell Chemotaxis Oxidation-reduction Process
Pathways		Keratinization	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Interacting Genes		75 interacting genes: ADAMTSL4 AEN AMMECR1 AVPI1 BAHD1 BCL6B CARD9 CATSPER1 CBX2 CHIC2 CHRD CREB5 CXCL16 DAAM2 DHX57 DKK1 DOCK2 ECE1 FAM76B GLRX3 HOXA1 HPCAL1 HSD3B7 KRTAP10-3 KRTAP12-1 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E MAPKBP1 MEOX2 MOBP NECTIN2 NOTCH2NLA NPDC1 NR4A1 OTX1 PID1 PIN1 POM121L8P PRM2 PRPF31 RSPO2 SHFL SLC23A1 SLC6A20 SPATA8 SPRY1 SPRY2 TULP3 WT1 ZBTB24 ZNF101 ZNF124 ZNF264 ZNF286A ZNF329 ZNF417 ZNF433 ZNF439 ZNF440 ZNF559 ZNF572 ZNF581 ZNF587 ZNF785 ZSCAN12 ZSCAN26	11 interacting genes: DAPP1 ICAM1 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 NOTCH2NLA PYGL SPRY2
Entrez ID		386677	80270
HPRD ID		11184	09680
Ensembl ID		ENSG00000215455	ENSG00000099377
Uniprot IDs		P60331	Q9H2F3
PDB IDs
Enriched GO Terms of Interacting Partners?
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