DKK1

Description		dickkopf WNT signaling pathway inhibitor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Learning Or Memory Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Binding Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Synaptic Transmission, Glutamatergic Limb Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Motor Learning Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Modulation Of Age-related Behavioral Decline Synapse Pruning Positive Regulation Of Neuron Death Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Tau-protein Kinase Activity Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 27577874 21076409 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9
Entrez ID		22943
HPRD ID		05544
Ensembl ID		ENSG00000107984
Uniprot IDs		I1W660 O94907
PDB IDs		3S2K 3S8V 3SOQ 5FWW 5GJE
Enriched GO Terms of Interacting Partners?
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