DKK1 and LRP6

Number of citations of the paper that reports this interaction (PubMedID 11357136)
326

Data Source:
HPRD (in vivo)

		DKK1	LRP6
Description		dickkopf WNT signaling pathway inhibitor 1	LDL receptor related protein 6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane	Extracellular Region Cell Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Synapse Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome
	Molecular Function	Protein Binding Growth Factor Activity Co-receptor Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Coreceptor Activity Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Apolipoprotein Binding Identical Protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Learning Or Memory Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Binding Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Synaptic Transmission, Glutamatergic Limb Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Motor Learning Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Modulation Of Age-related Behavioral Decline Synapse Pruning Positive Regulation Of Neuron Death Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Tau-protein Kinase Activity Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Cardiac Muscle Cell Differentiation	Gastrulation With Mouth Forming Second Neural Tube Closure Negative Regulation Of Protein Phosphorylation Pericardium Morphogenesis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Embryonic Pattern Specification Anterior/posterior Pattern Specification Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Cerebellum Morphogenesis Thalamus Development Cerebral Cortex Development Regulation Of Ossification Embryonic Limb Morphogenesis Midbrain Development Midbrain-hindbrain Boundary Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process External Genitalia Morphogenesis Odontogenesis Of Dentin-containing Tooth Response To Peptide Hormone Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Embryonic Camera-type Eye Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Convergent Extension Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Face Morphogenesis Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Trachea Cartilage Morphogenesis Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Protein Localization To Plasma Membrane Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Receptor-mediated Endocytosis Involved In Cholesterol Transport Wnt Signaling Pathway Involved In Somitogenesis Axis Elongation Involved In Somitogenesis Cell-cell Adhesion Toxin Transport Beta-catenin Destruction Complex Disassembly Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Bone properties (heel) ( 24430505) Chin dimples ( 27182965) Electrocardiographic traits ( 20062063) Fractures ( 30158200) Logical memory (delayed recall) in normal cognition ( 29274321) Metabolite levels ( 23823483) Monobrow ( 27182965) Periodontitis (Mean PAL) ( 24024966) QRS complex (12-leadsum) ( 27659466) QRS complex (Cornell) ( 27659466) QRS duration ( 27577874 21076409 27659466) Triglyceride levels x loop diuretics use interaction ( 31806883)	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)
Interacting Genes		8 interacting genes: CKAP4 DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9	16 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 DKK1 DKK2 FZD5 FZD8 GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A
Entrez ID		22943	4040
HPRD ID		05544	04617
Ensembl ID		ENSG00000107984	ENSG00000070018
Uniprot IDs		I1W660 O94907	O75581
PDB IDs		3S2K 3S8V 3SOQ 5FWW 5GJE	3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16
Enriched GO Terms of Interacting Partners?
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