F5 and PROS1

Number of citations of the paper that reports this interaction (PubMedID 8428962)
40

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		F5	PROS1
Description		coagulation factor V	protein S
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Copper Ion Binding Protein Binding	Endopeptidase Inhibitor Activity Calcium Ion Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Blood Coagulation Blood Circulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs		Drotrecogin alfa Thrombomodulin Alfa Protein S human Anti-inhibitor coagulant complex	Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate
Diseases		Inherited thrombophilia Factor V deficiency; Owren disease	Inherited thrombophilia
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 30072576 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Ischemic stroke ( 26732560) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 25631615 31798171) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 22672568 31676865) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Systemic lupus erythematosus ( 28714469)
Interacting Genes		11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2	10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3
Entrez ID		2153	5627
HPRD ID		01964	01473
Ensembl ID		ENSG00000198734	ENSG00000184500
Uniprot IDs		P12259	A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs		1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C	1Z6C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?