F5 and PROC

Number of citations of the paper that reports this interaction (PubMedID 7989361)
60

Data Source:
HPRD (in vitro)

		F5	PROC
Description		coagulation factor V	protein C, inactivator of coagulation factors Va and VIIIa
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Copper Ion Binding Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Blood Coagulation Blood Circulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating	Proteolysis ER To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Drotrecogin alfa Thrombomodulin Alfa Protein S human Anti-inhibitor coagulant complex	Menadione Sodium Tetradecyl Sulfate Cupric Chloride Protein S human
Diseases		Inherited thrombophilia Factor V deficiency; Owren disease	Inherited thrombophilia
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 30072576 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Ischemic stroke ( 26732560) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 25631615 31798171) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 22672568 31676865) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)
Interacting Genes		11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2	14 interacting genes: CP CSNK2B F2 F5 F8 GGCX NGLY1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		2153	5624
HPRD ID		01964	01466
Ensembl ID		ENSG00000198734	ENSG00000115718
Uniprot IDs		P12259	P04070
PDB IDs		1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C	1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7
Enriched GO Terms of Interacting Partners?
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