PROS1 and TYRO3

Number of citations of the paper that reports this interaction (PubMedID 8641360)
12

Data Source:
HPRD (in vivo)

		PROS1	TYRO3
Description		protein S	TYRO3 protein tyrosine kinase
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Cell Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding	Virus Receptor Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration	Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Viral Entry Into Host Cell Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs		Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate
Diseases		Inherited thrombophilia
GWAS		Systemic lupus erythematosus ( 28714469)	Blood protein levels ( 30072576) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	24 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LNX1 MDFI PIK3R1 PROS1 SRC TNIP1 YES1
Entrez ID		5627	7301
HPRD ID		01473	02641
Ensembl ID		ENSG00000184500	ENSG00000092445
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	H0YNK6 Q06418
PDB IDs		1Z6C	1RHF
Enriched GO Terms of Interacting Partners?
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