PROS1 and C4BPB

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (unspecified method, affinity chromatography technology)
HPRD (in vitro)

		PROS1	C4BPB
Description		protein S	complement component 4 binding protein beta
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding	Protein Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration	Complement Activation, Classical Pathway Blood Coagulation Response To Symbiotic Bacterium Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate	Zinc
Diseases		Inherited thrombophilia	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Systemic lupus erythematosus ( 28714469)	C4b binding protein levels ( 20212171) Hip circumference ( 28552196)
Interacting Genes		10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	1 interacting genes: PROS1
Entrez ID		5627	725
HPRD ID		01473	00404
Ensembl ID		ENSG00000184500	ENSG00000123843
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	P20851
PDB IDs		1Z6C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?