DVL2 and PCBD1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		DVL2	PCBD1
Description		dishevelled segment polarity protein 2	pterin-4 alpha-carbinolamine dehydratase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome Lateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle	Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Protein Self-association Rac GTPase Binding	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription By RNA Polymerase II Segment Specification Heart Development Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Beta-catenin Destruction Complex Disassembly	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Phenylalanine metabolism
Drugs			L-erythro-7,8-dihydrobiopterin
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Metabolite levels ( 31628463) Metabolite levels (small molecules and protein measures) ( 27005778)	Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)
Interacting Genes		102 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 KLHL12 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL NUP88 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 VANGL1 VHL WAS WT1 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581	49 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714
Entrez ID		1856	5092
HPRD ID		03690	00523
Ensembl ID		ENSG00000004975	ENSG00000166228
Uniprot IDs		O14641	P61457
PDB IDs		2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3
Enriched GO Terms of Interacting Partners?
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