Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
DVL2 and ARRB2
Number of citations of the paper that reports this interaction (PubMedID
12958364
)
137
Data Source:
HPRD
(in vivo)
DVL2
ARRB2
Description
dishevelled segment polarity protein 2
arrestin beta 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Dendritic Spine
Intracellular Membrane-bounded Organelle
Postsynaptic Membrane
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein Binding, Bridging
Identical Protein Binding
Protein Self-association
Rac GTPase Binding
G Protein-coupled Receptor Binding
Signaling Receptor Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Type 1 Angiotensin Receptor Binding
D1 Dopamine Receptor Binding
Follicle-stimulating Hormone Receptor Binding
Type 2A Serotonin Receptor Binding
Platelet Activating Factor Receptor Binding
Identical Protein Binding
Protein Kinase B Binding
Protein-containing Complex Binding
Mitogen-activated Protein Kinase Binding
Molecular Adaptor Activity
14-3-3 Protein Binding
Arrestin Family Protein Binding
Biological Process
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Transcription By RNA Polymerase II
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Negative Regulation Of Protein Phosphorylation
G Protein-coupled Receptor Internalization
Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin
Positive Regulation Of Receptor Internalization
Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Dopamine Receptor Signaling Pathway
Brain Development
Adult Walking Behavior
Positive Regulation Of Gene Expression
Protein Transport
Protein Ubiquitination
Protein Deubiquitination
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Receptor Internalization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Toll-like Receptor Signaling Pathway
Negative Regulation Of GTPase Activity
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Follicle-stimulating Hormone Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Calcium Ion Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Excitatory Postsynaptic Potential
Cell Chemotaxis
Regulation Of Androgen Receptor Signaling Pathway
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
Activation of SMO
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Drugs
Diseases
GWAS
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Lymphocyte counts (
27863252
)
Interacting Genes
102 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
NUP88
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UIMC1
USP5
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
51 interacting genes:
ADRB2
AGTR1
AP1B1
AP2M1
ARF6
AVPR2
C5AR1
CDC42
CLTC
CSNK2A1
CSNK2A2
CXCR4
CYTH2
DVL2
EGFR
FLNA
FZD4
GRK2
HCRTR1
HIPK3
HTR2C
ITCH
LHCGR
LIMK1
MAP2K4
MAP3K5
MAPK1
MAPK10
MAPK9
MDM2
MED8
NDUFS7
NFKBIA
NTS
NTSR1
OPRD1
OXER1
OXTR
PDE4D
PRKN
PTAFR
PTGDS
RAF1
RALGDS
RHO
SLC9A5
SMARCC2
STC2
TGFBR3
TRH
UBC
Entrez ID
1856
409
HPRD ID
03690
00147
Ensembl ID
ENSG00000004975
ENSG00000141480
Uniprot IDs
O14641
K7ENA6
P32121
Q59EM5
Q68DZ5
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?