DVL2 and ZBTB48

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		DVL2	ZBTB48
Description		dishevelled segment polarity protein 2	zinc finger and BTB domain containing 48
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome Lateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle	Chromosome, Telomeric Region Nucleoplasm Cytosol
	Molecular Function	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Protein Self-association Rac GTPase Binding	Double-stranded Telomeric DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription By RNA Polymerase II Segment Specification Heart Development Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Beta-catenin Destruction Complex Disassembly	Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Transcription, DNA-templated
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Metabolite levels ( 31628463) Metabolite levels (small molecules and protein measures) ( 27005778)
Interacting Genes		102 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 KLHL12 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL NUP88 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 VANGL1 VHL WAS WT1 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581	18 interacting genes: C11orf58 CDK2AP2 CDKN1A DVL2 DVL3 EP300 GPATCH2L ILK KRTAP10-5 LLCFC1 NME7 PNRC2 RGS2 TNFRSF14 TRIM41 UPF2 ZBTB7A ZBTB8A
Entrez ID		1856	3104
HPRD ID		03690	01316
Ensembl ID		ENSG00000004975	ENSG00000204859
Uniprot IDs		O14641	A8K291 B2R702 P10074
PDB IDs		2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3	3B84 5YJ3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?