CHRM2 and SET

Number of citations of the paper that reports this interaction (PubMedID 17065150)
10

Data Source:
BioGRID (pull down)

		CHRM2	SET
Description		cholinergic receptor muscarinic 2	SET nuclear proto-oncogene
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cell Junction Dendrite Clathrin-coated Vesicle Membrane Asymmetric Synapse Symmetric Synapse Neuronal Cell Body Axon Terminus Synapse Glutamatergic Synapse Cholinergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Arrestin Family Protein Binding	DNA Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding
	Biological Process	Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Membrane Organization G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	DNA Replication Nucleosome Assembly Nucleosome Disassembly Viral Process Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Histone Acetylation Regulation Of MRNA Stability Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
Drugs		Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Loxapine Carbachol Promazine Hyoscyamine Cyproheptadine Pethidine Imipramine Methylscopolamine bromide Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine Methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium chloride Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine ALKS 27 Fesoterodine Hexocyclium Dimetindene Aclidinium Umeclidinium Dosulepin Etoperidone Imidafenacin Butylscopolamine
Diseases
GWAS		Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Pulse pressure ( 30224653) Resting heart rate ( 29769521 27798624)	Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		10 interacting genes: GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 RGS7 SAG SET	54 interacting genes: ANP32A APEX1 APP CALM1 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H2BC1 H3-3A H3-4 H4-16 H4C14 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PIK3CG PPP2CA PPP2R1B PRKAR1A PTMA RAC1 SDCBP SETBP1 SGO1 TAF1A TERF1 TERF2 TERF2IP THAP7 TREX1 UCHL5 XRCC6
Entrez ID		1129	6418
HPRD ID		00328	09023
Ensembl ID		ENSG00000181072	ENSG00000119335
Uniprot IDs		A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1	A0A024R895 A0A0C4DFV9 Q01105 Q5VXV3
PDB IDs		1LUB 3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK	2E50
Enriched GO Terms of Interacting Partners?
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