CHRM2 and GNG2

Number of citations of the paper that reports this interaction (PubMedID 9063897)
21

Data Source:
HPRD (in vivo)

		CHRM2	GNG2
Description		cholinergic receptor muscarinic 2	G protein subunit gamma 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cell Junction Dendrite Clathrin-coated Vesicle Membrane Asymmetric Synapse Symmetric Synapse Neuronal Cell Body Axon Terminus Synapse Glutamatergic Synapse Cholinergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Heterotrimeric G-protein Complex Plasma Membrane Membrane G-protein Beta/gamma-subunit Complex Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Arrestin Family Protein Binding	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Membrane Organization G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Cell Proliferation Platelet Activation Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Loxapine Carbachol Promazine Hyoscyamine Cyproheptadine Pethidine Imipramine Methylscopolamine bromide Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine Methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium chloride Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine ALKS 27 Fesoterodine Hexocyclium Dimetindene Aclidinium Umeclidinium Dosulepin Etoperidone Imidafenacin Butylscopolamine	Halothane
Diseases
GWAS		Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Pulse pressure ( 30224653) Resting heart rate ( 29769521 27798624)	Chronic obstructive pulmonary disease ( 25584925) Cognitive decline rate in late mild cognitive impairment ( 26252872) Craniofacial microsomia ( 26853712) High density lipoprotein cholesterol levels ( 29403010) Lung cancer (smoking interaction) ( 24658283) Non-melanoma skin cancer ( 23548203) Post bronchodilator FEV1/FVC ratio ( 26634245) Triglyceride levels ( 31170924) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		10 interacting genes: GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 RGS7 SAG SET	15 interacting genes: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R
Entrez ID		1129	54331
HPRD ID		00328	16234
Ensembl ID		ENSG00000181072	ENSG00000186469
Uniprot IDs		A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1	P59768
PDB IDs		1LUB 3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK	4KFM 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OS9 6OSA 6OT0
Enriched GO Terms of Interacting Partners?
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