FRS3 and TNS1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		FRS3	TNS1
Description		fibroblast growth factor receptor substrate 3	tensin 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Cytoplasm Cytoskeleton Focal Adhesion Cell Surface
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	RNA Binding Actin Binding Protein Binding
	Biological Process	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Cell-substrate Junction Assembly Fibroblast Migration
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma and hay fever ( 24388013) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) FEV1 ( 30804560) Height ( 21998595 28552196 20881960 25282103 25429064) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Intraocular pressure ( 29617998 29785010 30054594 29235454) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Mitral valve prolapse ( 26301497) Pulmonary function ( 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP	7 interacting genes: CAPN2 FRS3 KLF10 OSGEP PPP1CC PTK2 YWHAZ
Entrez ID		10817	7145
HPRD ID		06373	02512
Ensembl ID		ENSG00000137218	ENSG00000079308
Uniprot IDs		A0A140VJJ7 O43559	A1L0S7 B2RU35 B7Z6H8 E9PF55 E9PGF5 Q0VG54 Q0VG55 Q59G71 Q86VB0 Q9HBL0
PDB IDs		2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?
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