TNS1 and CAPN2

Number of citations of the paper that reports this interaction (PubMedID 11023826)
17

Data Source:
HPRD (in vitro, in vivo)

		TNS1	CAPN2
Description		tensin 1	calpain 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Focal Adhesion Cell Surface	Chromatin Nucleus Cytoplasm Mitochondrial Intermembrane Space Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum
	Molecular Function	RNA Binding Actin Binding Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Enzyme Binding Protein-containing Complex Binding
	Biological Process	Cell-substrate Junction Assembly Fibroblast Migration	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Extracellular Matrix Disassembly Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Positive Regulation Of Neuron Death Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways			Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma and hay fever ( 24388013) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) FEV1 ( 30804560) Height ( 21998595 28552196 20881960 25282103 25429064) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Intraocular pressure ( 29617998 29785010 30054594 29235454) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Mitral valve prolapse ( 26301497) Pulmonary function ( 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 27841878 30578418)	Blood protein levels ( 30072576 29875488) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Waist circumference ( 31170924)
Interacting Genes		7 interacting genes: CAPN2 FRS3 KLF10 OSGEP PPP1CC PTK2 YWHAZ	22 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 F2RL1 GAS2 GRK2 KNG1 MAPK1 MAPT MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21
Entrez ID		7145	824
HPRD ID		02512	00254
Ensembl ID		ENSG00000079308	ENSG00000162909
Uniprot IDs		A1L0S7 B2RU35 B7Z6H8 E9PF55 E9PGF5 Q0VG54 Q0VG55 Q59G71 Q86VB0 Q9HBL0	B4DN77 P17655 Q59EF6
PDB IDs			1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
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