FRS3 and NUMB

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		FRS3	NUMB
Description		fibroblast growth factor receptor substrate 3	NUMB endocytic adaptor protein
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GO Annotations	Cellular Component	Plasma Membrane	Nucleus Cytoplasm Early Endosome Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Macular thickness ( 30535121) Multisite chronic pain ( 31194737)
Interacting Genes		28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP	33 interacting genes: AP2A1 AP2A2 APP DNAJC5 DPYSL2 EGFR EPS15 FBXO7 FRS3 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 OLIG1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 TERF2
Entrez ID		10817	8650
HPRD ID		06373	04767
Ensembl ID		ENSG00000137218	ENSG00000133961
Uniprot IDs		A0A140VJJ7 O43559	A0A024R681 A0A024R684 A0A024R6C4 A0A024R6F4 P49757
PDB IDs		2KUP 2KUQ 2YS5 2YT2	5NJJ 5NJK
Enriched GO Terms of Interacting Partners?
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