PRPF8 and ERG

Number of citations of the paper that reports this interaction (PubMedID 21575865)
167

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PRPF8	ERG
Description		pre-mRNA processing factor 8	ETS transcription factor ERG
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm U5 SnRNP Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nuclear Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)	Ewing's sarcoma Prostate cancer
GWAS		Blood protein levels ( 28240269) Calcium levels ( 20705733) Ischemic stroke ( 29531354) Stroke ( 29531354)	Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Metabolite levels (HVA) ( 23319000) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252) Plateletcrit ( 27863252) Pulse pressure ( 27841878 30578418) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		14 interacting genes: ABCA1 DHX9 ERG GPKOW HNRNPH2 NEDD4 PIN1 PRPF19 SERPINB2 SND1 SNRNP200 UBC UBE2I ZNF830	73 interacting genes: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2
Entrez ID		10594	2078
HPRD ID		06295	01298
Ensembl ID		ENSG00000174231	ENSG00000157554
Uniprot IDs		Q6P2Q9	A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308
PDB IDs		3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9	1SXE 4IRG 4IRH 4IRI 5YBC 5YBD
Enriched GO Terms of Interacting Partners?
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