ZC3H7A - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	PMM2	phosphomannomutase 2	Defective PMM2 causes PMM2-CDG Synthesis of GDP-mannose		Congenital disorders of glycosylation (CDG) type I
	COL7A1	collagen type VII alpha 1 chain	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization		Epidermolysis bullosa, dysprophic, including: ; Epidermolysis bullosa dystrophica, AD; Epidermolysis bullosa dystrophica, AR; Epidermolysis bullosa pruriginosa; Epidermolysis bullosa, pretibial Transient bullous dermolysis of the newborn
	LARP4	La ribonucleoprotein 4
	MIR16-2	microRNA 16-2
	MIR29A	microRNA 29a
	MIR7-1	microRNA 7-1
	MIR92A2	microRNA 92a-2
	MORF4L1	mortality factor 4 like 1	HATs acetylate histones
	PAK1	p21 (RAC1) activated kinase 1	Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Fostamatinib
	STK3	serine/threonine kinase 3	Signaling by Hippo	Fostamatinib
	WDR83	WD repeat domain 83	MAP2K and MAPK activation

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