Search Results for: SCAP

12 interactions involving SCAP - SREBF chaperone found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel ATG16L1 autophagy related 16 like 1
  • Macroautophagy
  • Crohn's disease
Novel DHX30 DExH-box helicase 30
Novel HIPK2 homeodomain interacting protein kinase 2
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression
  • SUMOylation of transcription cofactors
  • Physiological factors
  • Regulation of TP53 Activity through Phosphorylation
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of MECP2 expression and activity
  • Fostamatinib
Novel KLHL18 kelch like family member 18
Novel LAMC2 laminin subunit gamma 2
  • Degradation of the extracellular matrix
  • Degradation of the extracellular matrix
  • Assembly of collagen fibrils and other multimeric structures
  • Anchoring fibril formation
  • Laminin interactions
  • Laminin interactions
  • Non-integrin membrane-ECM interactions
  • Type I hemidesmosome assembly
  • MET activates PTK2 signaling
  • Attachment of bacteria to epithelial cells
  • Formation of the dystrophin-glycoprotein complex (DGC)
  • Formation of the dystrophin-glycoprotein complex (DGC)
  • Developmental Lineage of Pancreatic Ductal Cells
  • Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
Novel NDUFAF3 NADH:ubiquinone oxidoreductase complex assembly factor 3
  • Complex I biogenesis
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
Novel WDR6 WD repeat domain 6
  • RHOU GTPase cycle
  • RHOV GTPase cycle
  • RND3 GTPase cycle
  • RND2 GTPase cycle
  • RND1 GTPase cycle
INSIG1 insulin induced gene 1
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
INSIG2 insulin induced gene 2
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
PGRMC1 progesterone receptor membrane component 1
  • Neutrophil degranulation
  • Dextromethorphan
  • Nortriptyline
  • Sertraline
SEC24B SEC24 homolog B, COPII component
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • COPII-mediated vesicle transport
  • MHC class II antigen presentation
  • Cargo concentration in the ER
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
  • Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SREBF2 sterol regulatory element binding transcription factor 2
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • Cholesterol biosynthesis
  • PPARA activates gene expression
  • Activation of gene expression by SREBF (SREBP)
  • Activation of gene expression by SREBF (SREBP)
  • Transcriptional regulation of white adipocyte differentiation
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination

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