PALS2 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ADGRA1	adhesion G protein-coupled receptor A1
Novel	ARF5	ARF GTPase 5	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Novel	MKRN2	makorin ring finger protein 2
Novel	OSBPL3	oxysterol binding protein like 3	Synthesis of bile acids and bile salts
Novel	PTF1A	pancreas associated transcription factor 1a	Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells		Permanent neonatal diabetes mellitus (PNDM)
Novel	TACR3	tachykinin receptor 3	Tachykinin receptors bind tachykinins G alpha (q) signalling events	Osanetant Talnetant Pavinetant	Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
	AATF	apoptosis antagonizing transcription factor	NRAGE signals death through JNK
	ABCA1	ATP binding cassette subfamily A member 1	PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	ATP Glyburide Probucol	Tangier disease Hypoalphalipoproteinemia
	ARHGAP18	Rho GTPase activating protein 18	RHOA GTPase cycle RHOC GTPase cycle
	DIS3	DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	DNM2	dynamin 2	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1		Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
	DYNLRB1	dynein light chain roadblock-type 1	Intraflagellar transport
	EIF3G	eukaryotic translation initiation factor 3 subunit G	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
	EXOSC10	exosome component 10	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	EXOSC2	exosome component 2	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	EXOSC4	exosome component 4	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	EXOSC5	exosome component 5	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	EXOSC6	exosome component 6	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	EXOSC7	exosome component 7	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	EXOSC8	exosome component 8	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay

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