|
Novel |
ALKBH2 |
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase |
- ALKBH2 mediated reversal of alkylation damage
|
|
|
|
Novel |
POU4F1 |
POU class 4 homeobox 1 |
- Regulation of TP53 Activity through Association with Co-factors
|
|
|
|
Novel |
RBM26 |
RNA binding motif protein 26 |
|
|
|
|
Novel |
SLITRK6 |
SLIT and NTRK like family member 6 |
- Receptor-type tyrosine-protein phosphatases
|
|
|
|
Novel |
SPRY2 |
sprouty RTK signaling antagonist 2 |
- Spry regulation of FGF signaling
- EGFR downregulation
|
|
|
|
|
AQP2 |
aquaporin 2 |
- Vasopressin regulates renal water homeostasis via Aquaporins
- Passive transport by Aquaporins
|
|
- Congenital nephrogenic diabetes insipidus (NDI)
|
|
|
ITCH |
itchy E3 ubiquitin protein ligase |
- Downregulation of ERBB4 signaling
- NOD1/2 Signaling Pathway
- Activated NOTCH1 Transmits Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Degradation of GLI1 by the proteasome
- Hedgehog 'on' state
- Regulation of necroptotic cell death
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Negative regulators of DDX58/IFIH1 signaling
- SARS-CoV-1 activates/modulates innate immune responses
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
LYN |
LYN proto-oncogene, Src family tyrosine kinase |
- GPVI-mediated activation cascade
- Signaling by SCF-KIT
- Signaling by SCF-KIT
- Regulation of KIT signaling
- Cell surface interactions at the vascular wall
- FCGR activation
- PECAM1 interactions
- Fc epsilon receptor (FCERI) signaling
- Fc epsilon receptor (FCERI) signaling
- EPH-Ephrin signaling
- Role of LAT2/NTAL/LAB on calcium mobilization
- Role of LAT2/NTAL/LAB on calcium mobilization
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- FCERI mediated NF-kB activation
- Co-stimulation by CD28
- Co-inhibition by CTLA4
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- Dectin-2 family
- CD209 (DC-SIGN) signaling
- CD22 mediated BCR regulation
- Cyclin D associated events in G1
- Platelet Adhesion to exposed collagen
- Signaling by Erythropoietin
- Signaling by Erythropoietin
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
- Erythropoietin activates Phospholipase C gamma (PLCG)
- Erythropoietin activates STAT5
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Regulation of signaling by CBL
- Regulation of signaling by CBL
- FCGR3A-mediated IL10 synthesis
- FCGR3A-mediated phagocytosis
- Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
- Signaling by CSF3 (G-CSF)
- Signaling by CSF3 (G-CSF)
- Signaling by CSF1 (M-CSF) in myeloid cells
- Inactivation of CSF3 (G-CSF) signaling
- Inactivation of CSF3 (G-CSF) signaling
- Growth hormone receptor signaling
- Growth hormone receptor signaling
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
|
- Dasatinib
- 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
- Bosutinib
- Ponatinib
- Nintedanib
- Fostamatinib
|
|
|
|
NEDD4 |
NEDD4 E3 ubiquitin protein ligase |
- ISG15 antiviral mechanism
- Downregulation of ERBB4 signaling
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
NEDD4L |
NEDD4 like E3 ubiquitin protein ligase |
- Budding and maturation of HIV virion
- Downregulation of TGF-beta receptor signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Stimuli-sensing channels
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
SMURF1 |
SMAD specific E3 ubiquitin protein ligase 1 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Asymmetric localization of PCP proteins
- Hedgehog 'on' state
- Hedgehog 'on' state
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
UQCRH |
ubiquinol-cytochrome c reductase hinge protein |
- Respiratory electron transport
- Complex III assembly
- Complex III assembly
|
- 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
- 6-Hydroxy-5-undecyl-4,7-benzothiazoledione
- Azoxystrobin
- (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
- (S)-famoxadone
- METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
- 2-Nonyl-4-quinolinol 1-oxide
- Ubiquinone Q2
|
|
|
|
WWP2 |
WW domain containing E3 ubiquitin protein ligase 2 |
- Regulation of PTEN stability and activity
- RHOQ GTPase cycle
- RHOJ GTPase cycle
- RHOU GTPase cycle
- NOTCH3 Activation and Transmission of Signal to the Nucleus
|
|
|
|
|
YAP1 |
Yes1 associated transcriptional regulator |
- Nuclear signaling by ERBB4
- Signaling by Hippo
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- RUNX2 regulates osteoblast differentiation
- RUNX3 regulates YAP1-mediated transcription
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
- Formation of axial mesoderm
- Zygotic genome activation (ZGA)
- Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
- Regulation of PD-L1(CD274) transcription
- Developmental Lineage of Pancreatic Ductal Cells
|
|
|