NDFIP2 and ALKBH2

		NDFIP2	ALKBH2
Description		Nedd4 family interacting protein 2	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endosome Endoplasmic Reticulum Golgi Apparatus Endosome Membrane Membrane Multivesicular Body Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding WW Domain Binding	RDNA Binding Protein Binding Ferrous Iron Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity Cytosine C-5 DNA Demethylase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein Transport	DNA Repair DNA Alkylation Repair DNA Damage Response
Pathways			ALKBH2 mediated reversal of alkylation damage
Drugs			Ascorbic acid
Diseases
GWAS		Bullous pemphigoid ( 34011352) Leisure-time exercise behaviour (age-stratified) ( 30102679) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Pancreatic cancer ( 20686608) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: AQP2 ITCH LYN NEDD4 NEDD4L SMURF1 UQCRH WWP2 YAP1	1 interacting genes: GOLGA2
Entrez ID		54602	121642
HPRD ID		17629	14712
Ensembl ID		ENSG00000102471	ENSG00000189046
Uniprot IDs		B4DGY6 Q9NV92	Q6NS38
PDB IDs			3BTX 3BTY 3BTZ 3BU0 3BUC 3H8O 3H8R 3H8X 3RZG 3RZH 3RZJ 3RZK 3RZL 3RZM 3S57 3S5A 4MG2 4MGT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Transport Protein Polyubiquitination Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity Receptor Metabolic Process Regulation Of Cell Projection Organization C-X-C Chemokine Receptor CXCR4 Signaling Pathway Protein Monoubiquitination Bud Elongation Involved In Lung Branching Regulation Of Nervous System Development Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Developmental Process Positive Regulation Of Protein Metabolic Process Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Synapse Organization Regulation Of Monoatomic Cation Transmembrane Transport Branch Elongation Of An Epithelium Negative Regulation Of Signal Transduction Negative Regulation Of Sodium Ion Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Signaling Negative Regulation Of Cell Communication Tolerance Induction Proline-rich Region Binding Protein Ubiquitination Axis Elongation Negative Regulation Of Transmembrane Transport Innervation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Dendrite Extension Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Metal Ion Transport Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Neurogenesis Positive Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Protein Glycosylation Golgi Cis Cisterna Regulation Of Protein Glycosylation Positive Regulation Of Protein Modification Process Golgi Ribbon Formation Regulation Of Protein Modification Process Golgi Membrane Asymmetric Cell Division Importin-alpha Family Protein Binding Golgi Disassembly Meiotic Spindle Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Glycoprotein Biosynthetic Process Meiotic Spindle Organization WW Domain Binding Negative Regulation Of Protein Binding Microtubule Nucleation Negative Regulation Of Transporter Activity Multivesicular Body Membrane Regulation Of Glycoprotein Biosynthetic Process Syntaxin Binding COPII-coated ER To Golgi Transport Vesicle Regulation Of Protein Binding Centrosome Cycle Cis-Golgi Network Golgi Apparatus Intracellular Transport Mitotic Spindle Assembly Protein Homotetramerization Golgi Cisterna Membrane Cellular Localization Establishment Of Localization In Cell Regulation Of Protein Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Organelle Disassembly Microtubule Organizing Center Organization Mitotic Spindle Organization Spindle Assembly Protein Tetramerization Negative Regulation Of Autophagy Positive Regulation Of Protein Ubiquitination Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Protein Transport Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Post-translational Protein Modification Mitotic Spindle Negative Regulation Of Establishment Of Protein Localization
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