NDFIP2 and POU4F1

		NDFIP2	POU4F1
Description		Nedd4 family interacting protein 2	POU class 4 homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endosome Endoplasmic Reticulum Golgi Apparatus Endosome Membrane Membrane Multivesicular Body Membrane Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Neuron Projection RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding WW Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding GTPase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Suckling Behavior Ventricular Compact Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Synapse Assembly Mesoderm Development Heart Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration In Hindbrain Trigeminal Nerve Development Central Nervous System Neuron Differentiation Habenula Development Neuron Differentiation Neuron Projection Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Sensory System Development Peripheral Nervous System Neuron Differentiation Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Regulation Of DNA-binding Transcription Factor Activity Proprioception Involved In Equilibrioception Neuron Apoptotic Process Regulation Of Cell Cycle Innervation Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Bullous pemphigoid ( 34011352) Leisure-time exercise behaviour (age-stratified) ( 30102679) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Pancreatic cancer ( 20686608) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		9 interacting genes: AQP2 ITCH LYN NEDD4 NEDD4L SMURF1 UQCRH WWP2 YAP1	4 interacting genes: ESR1 EWSR1 MAPRE3 RIT2
Entrez ID		54602	5457
HPRD ID		17629	03379
Ensembl ID		ENSG00000102471	ENSG00000152192
Uniprot IDs		B4DGY6 Q9NV92	Q01851
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Transport Protein Polyubiquitination Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity Receptor Metabolic Process Regulation Of Cell Projection Organization C-X-C Chemokine Receptor CXCR4 Signaling Pathway Protein Monoubiquitination Bud Elongation Involved In Lung Branching Regulation Of Nervous System Development Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Developmental Process Positive Regulation Of Protein Metabolic Process Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Synapse Organization Regulation Of Monoatomic Cation Transmembrane Transport Branch Elongation Of An Epithelium Negative Regulation Of Signal Transduction Negative Regulation Of Sodium Ion Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Signaling Negative Regulation Of Cell Communication Tolerance Induction Proline-rich Region Binding Protein Ubiquitination Axis Elongation Negative Regulation Of Transmembrane Transport Innervation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Dendrite Extension Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Metal Ion Transport Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Neurogenesis Positive Regulation Of Macromolecule Metabolic Process	Calmodulin Binding Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Mammary Gland Branching Involved In Pregnancy Regulation Of Gene Expression Antral Ovarian Follicle Growth Regulation Of Nitric-oxide Synthase Activity Identical Protein Binding Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Neuron Projection Development Dendritic Tree Mitotic Spindle Astral Microtubule End Microtubule End Nitric-oxide Synthase Regulator Activity Neuron To Neuron Synapse Branching Involved In Prostate Gland Morphogenesis Regulation Of Macromolecule Metabolic Process Estrogen Response Element Binding Prostate Gland Growth Regulation Of Canonical NF-kappaB Signal Transduction Vagina Development Regulation Of Cdc42 Protein Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Cellular Response To Estrogen Stimulus Branch Elongation Of An Epithelium Axis Elongation Mammary Gland Alveolus Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Mammary Gland Epithelial Cell Proliferation Regulation Of RNA Biosynthetic Process Female Genitalia Development Regulation Of Metabolic Process Golgi Apparatus Regulation Of Oxidoreductase Activity Positive Regulation Of Cell Projection Organization Protein Localization To Microtubule Behavioral Response To Cocaine Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway
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