IFT88 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ALDH8A1	aldehyde dehydrogenase 8 family member A1	RA biosynthesis pathway
Novel	MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5		Fostamatinib
Novel	PCOTH	prostate and testis expressed opposite C1QTNF9B and MIPEP
Novel	PDX1	pancreatic and duodenal homeobox 1	Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells		Permanent neonatal diabetes mellitus (PNDM) Pancreatic agenesis Maturity onset diabetes of the young (MODY)
Novel	SAP18	Sin3A associated protein 18	HDACs deacetylate histones NoRC negatively regulates rRNA expression mRNA Splicing - Major Pathway Potential therapeutics for SARS
Novel	TRIM24	tripartite motif containing 24	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions
	CACNA1C	calcium voltage-gated channel subunit alpha1 C	Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Ibutilide Diltiazem Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Barnidipine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Isavuconazole Propiverine Bioallethrin Bioallethrin Fish oil	Brugada syndrome (BRS) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
	CAPN7	calpain 7	Degradation of the extracellular matrix
	CCDC120	coiled-coil domain containing 120
	DSCAM	DS cell adhesion molecule	DSCAM interactions DSCAM interactions
	EEF2KMT	eukaryotic elongation factor 2 lysine methyltransferase	Protein methylation
	EML2	EMAP like 2
	FBXO7	F-box protein 7	Neddylation Antigen processing: Ubiquitination & Proteasome degradation		Parkinson's disease (PD)
	HUNK	hormonally up-regulated Neu-associated kinase
	ITPKB	inositol-trisphosphate 3-kinase B	Synthesis of IP3 and IP4 in the cytosol
	MSRB1	methionine sulfoxide reductase B1	Protein repair
	PRRC2A	proline rich coiled-coil 2A
	RPGR	retinitis pigmentosa GTPase regulator			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
	SMARCE1	SWI/SNF related BAF chromatin remodeling complex subunit E1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Phenethyl Isothiocyanate
	VHL	von Hippel-Lindau tumor suppressor	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation		von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma

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