IFT88 and ALDH8A1

		IFT88	ALDH8A1
Description		intraflagellar transport 88	aldehyde dehydrogenase 8 family member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Manchette Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Intraciliary Transport Particle B Motile Cilium Centriolar Satellite Ciliary Basal Body Sperm Flagellum Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Tip Ciliary Base Non-motile Cilium Sperm Head-tail Coupling Apparatus	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Kinesin Binding	Retinal Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Aminomuconate-semialdehyde Dehydrogenase Activity
	Biological Process	Kidney Development Cell Projection Organization Response To Silicon Dioxide Intraciliary Anterograde Transport Intraciliary Transport Positive Regulation Of Cilium Assembly Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly	Retinoic Acid Metabolic Process Retinal Metabolic Process 9-cis-retinoic Acid Biosynthetic Process L-kynurenine Catabolic Process
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	RA biosynthesis pathway
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)	Coronary artery calcification ( 23870195) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 30224653) Spleen volume ( 34128465)
Interacting Genes		14 interacting genes: CACNA1C CAPN7 CCDC120 DSCAM EEF2KMT EML2 FBXO7 HUNK ITPKB MSRB1 PRRC2A RPGR SMARCE1 VHL	1 interacting genes: APP
Entrez ID		8100	64577
HPRD ID		09000	06974
Ensembl ID		ENSG00000032742	ENSG00000118514
Uniprot IDs		A0A140VJL7 B3KX42 Q13099	Q9H2A2
PDB IDs
Enriched GO Terms of Interacting Partners?			Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Microtubule-based Transport Transport Along Microtubule Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Microtubule-based Movement Response To Silicon Dioxide Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Neuron Projection Development Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Plasma Membrane Bounded Cell Projection Organization Acetylcholine Receptor Binding Golgi-associated Vesicle
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