EXOSC5 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
Novel	HAMP	hepcidin antimicrobial peptide		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
Novel	KMT2A	lysine methyltransferase 2A	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Formation of WDR5-containing histone-modifying complexes Regulation of PD-L1(CD274) transcription Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Novel	PAF1	PAF1 component of Paf1/RNA polymerase II complex	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Novel	PRODH2	proline dehydrogenase 2	Glyoxylate metabolism and glycine degradation Proline catabolism
	ACOT11	acyl-CoA thioesterase 11	Mitochondrial Fatty Acid Beta-Oxidation
	ADAMTSL4	ADAMTS like 4	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Ectopia lentis
	BIRC2	baculoviral IAP repeat containing 2	Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
	BORCS6	BLOC-1 related complex subunit 6
	CALCOCO2	calcium binding and coiled-coil domain 2
	CCDC88B	coiled-coil and HOOK domain protein 88B
	CDK5RAP1	CDK5RAP1 mitochondrial tRNA methylthiotransferase
	CEP55	centrosomal protein 55
	CPSF7	cleavage and polyadenylation specific factor 7	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
	DAAM2	dishevelled associated activator of morphogenesis 2
	DDIT4L	DNA damage inducible transcript 4 like
	DHRS2	dehydrogenase/reductase 2
	DIS3	DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
	DMRTB1	DMRT like family B with proline rich C-terminal 1
	DOCK8	dedicator of cytokinesis 8	CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production	Non-syndromic autosomal dominant mental retardation
	EFHC2	EF-hand domain containing 2

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