Search Results for: DEDD

24 interactions involving DEDD - death effector domain containing found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Symbol Description Pathways Hide Drugs Hide Diseases Hide
Novel IRF9 interferon regulatory factor 9
  • Interferon gamma signaling
  • Interferon alpha/beta signaling
Novel MPZ myelin protein zero
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
  • Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Novel NR1I3 nuclear receptor subfamily 1 group I member 3
  • Doxylamine
  • Meclizine
  • Ketoconazole
  • Atorvastatin
  • Pheniramine
  • Prasterone
  • 16,17-Androstene-3-Ol
  • Resveratrol
  • Cholesterol
  • Phenolphthalein
  • 3,20-Pregnanedione
  • Hexestrol
  • Triclosan
Novel PRRC2C proline rich coiled-coil 2C
Novel SDHC succinate dehydrogenase complex subunit C
  • Respiratory electron transport
  • Citric acid cycle (TCA cycle)
  • Maturation of TCA enzymes and regulation of TCA cycle
  • 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
  • Ubiquinone Q1
Novel SLC19A2 solute carrier family 19 member 2
  • Vitamin B1 (thiamin) metabolism
Novel UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
  • Synthesis of UDP-N-acetyl-glucosamine
  • Uridine-Diphosphate-N-Acetylgalactosamine
  • Uridine-Diphosphate-N-Acetylglucosamine
Novel VPS26A VPS26 retromer complex component A
  • WNT ligand biogenesis and trafficking
APLP2 amyloid beta precursor like protein 2
  • Platelet degranulation
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
  • Zinc
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
APP amyloid beta precursor protein
  • Platelet degranulation
  • ECM proteoglycans
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • G alpha (q) signalling events
  • G alpha (i) signalling events
  • Lysosome Vesicle Biogenesis
  • Formyl peptide receptors bind formyl peptides and many other ligands
  • TAK1-dependent IKK and NF-kappa-B activation
  • The NLRP3 inflammasome
  • Advanced glycosylation endproduct receptor signaling
  • Advanced glycosylation endproduct receptor signaling
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Post-translational protein phosphorylation
  • TRAF6 mediated NF-kB activation
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Purinergic signaling in leishmaniasis infection
  • Amyloid fiber formation
  • Deferoxamine
  • Aluminium
  • Zinc
  • L-methionine (R)-S-oxide
  • Resveratrol
  • Tromethamine
  • Phenserine
  • Tetrathiomolybdate
  • CAD106
  • Mito-4509
  • Edonerpic
  • Dimercaprol
  • Copper
  • Florbetaben (18F)
  • Florbetapir (18F)
  • Flutemetamol (18F)
  • Gantenerumab
  • Aducanumab
  • Zinc acetate
  • Aluminium phosphate
  • Aluminum acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Lecanemab
  • Alzheimer's disease (AD)
BATF2 basic leucine zipper ATF-like transcription factor 2
CASP10 caspase 10
  • TP53 Regulates Transcription of Caspase Activators and Caspases
  • FasL/ CD95L signaling
  • TRAIL signaling
  • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
  • Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
CASP3 caspase 3
  • Activation of caspases through apoptosome-mediated cleavage
  • SMAC (DIABLO) binds to IAPs
  • SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
  • Apoptotic cleavage of cellular proteins
  • SMAC, XIAP-regulated apoptotic response
  • Apoptosis induced DNA fragmentation
  • Degradation of the extracellular matrix
  • Signaling by Hippo
  • NADE modulates death signalling
  • Stimulation of the cell death response by PAK-2p34
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Apoptotic cleavage of cell adhesion proteins
  • Caspase activation via Dependence Receptors in the absence of ligand
  • Caspase activation via Dependence Receptors in the absence of ligand
  • Other interleukin signaling
  • Pyroptosis
  • CASP4-mediated substrate cleavage
  • CASP5-mediated substrate cleavage
  • Pamidronic acid
  • Acetylsalicylic acid
  • Minocycline
  • 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
  • Emricasan
  • Incadronic acid
  • 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
  • methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
  • 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
  • [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
  • 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
  • (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
  • (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
  • N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
  • Tributyrin
  • Oleandrin
  • PAC-1
  • Glycyrrhizic acid
CASP8 caspase 8
  • Apoptotic cleavage of cellular proteins
  • Caspase activation via Death Receptors in the presence of ligand
  • NOD1/2 Signaling Pathway
  • TRIF-mediated programmed cell death
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Regulation by c-FLIP
  • RIPK1-mediated regulated necrosis
  • CASP8 activity is inhibited
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • CLEC7A/inflammasome pathway
  • Regulation of necroptotic cell death
  • Dimerization of procaspase-8
  • Activation, myristolyation of BID and translocation to mitochondria
  • Apoptotic execution phase
  • FasL/ CD95L signaling
  • TRAIL signaling
  • TLR3-mediated TICAM1-dependent programmed cell death
  • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
  • Microbial modulation of RIPK1-mediated regulated necrosis
  • Defective RIPK1-mediated regulated necrosis
  • Regulation of NF-kappa B signaling
  • Trichostatin A
  • AN-9
  • Bryostatin 1
  • Bardoxolone
  • Oleandrin
  • Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
CFLAR CASP8 and FADD like apoptosis regulator
  • TRAIL signaling
DEDD2 death effector domain containing 2
FADD Fas associated via death domain
  • Caspase activation via Death Receptors in the presence of ligand
  • TRIF-mediated programmed cell death
  • Regulation by c-FLIP
  • RIPK1-mediated regulated necrosis
  • CASP8 activity is inhibited
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • Regulation of necroptotic cell death
  • Dimerization of procaspase-8
  • FasL/ CD95L signaling
  • TRAIL signaling
  • TLR3-mediated TICAM1-dependent programmed cell death
  • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
  • Defective RIPK1-mediated regulated necrosis
GTF3C1 general transcription factor IIIC subunit 1
  • RNA Polymerase III Abortive And Retractive Initiation
  • RNA Polymerase III Transcription Initiation From Type 1 Promoter
  • RNA Polymerase III Transcription Initiation From Type 1 Promoter
  • RNA Polymerase III Transcription Initiation From Type 2 Promoter
  • RNA Polymerase III Transcription Initiation From Type 2 Promoter
GTF3C3 general transcription factor IIIC subunit 3
  • RNA Polymerase III Abortive And Retractive Initiation
  • RNA Polymerase III Transcription Initiation From Type 1 Promoter
  • RNA Polymerase III Transcription Initiation From Type 1 Promoter
  • RNA Polymerase III Transcription Initiation From Type 2 Promoter
  • RNA Polymerase III Transcription Initiation From Type 2 Promoter
HOXD4 homeobox D4
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis

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