HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols CTSB and CST7	Name 1 cathepsin B	Name2 cystatin F	Pathway 1 Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1	Pathway 2	Drugs 1 2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE	Drugs 2	Diseases 1 Tropical calcific pancreatitis	Diseases 2
Novel Novel	Symbols RNF10 and HTATSF1	Name 1 ring finger protein 10	Name2 HIV-1 Tat specific factor 1	Pathway 1	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RNF10 and NOC3L	Name 1 ring finger protein 10	Name2 NOC3 like DNA replication regulator	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ALK and PTN	Name 1 ALK receptor tyrosine kinase	Name2 pleiotrophin	Pathway 1 Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Pathway 2 Signaling by ALK Signaling by ALK MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Drugs 1 ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib	Drugs 2	Diseases 1 Non-small cell lung cancer	Diseases 2
Novel Novel	Symbols CSF1 and CSF1R	Name 1 colony stimulating factor 1	Name2 colony stimulating factor 1 receptor	Pathway 1 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation Signaling by CSF1 (M-CSF) in myeloid cells Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Other interleukin signaling Transcriptional Regulation by VENTX Signaling by CSF1 (M-CSF) in myeloid cells	Drugs 1	Drugs 2 Imatinib Sunitinib Linifanib 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib	Diseases 1	Diseases 2 Choriocarcinoma
Novel Novel	Symbols APCS and CRP	Name 1 amyloid P component, serum	Name2 C-reactive protein	Pathway 1 Amyloid fiber formation	Pathway 2 Classical antibody-mediated complement activation	Drugs 1 Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate	Drugs 2 N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139	Diseases 1	Diseases 2 Systemic lupus erythematosus
Novel Novel	Symbols CD180 and LY86	Name 1 CD180 molecule	Name2 lymphocyte antigen 86	Pathway 1 Toll Like Receptor 4 (TLR4) Cascade	Pathway 2 Toll Like Receptor 4 (TLR4) Cascade	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MUC5AC and GALNT14	Name 1 mucin 5AC, oligomeric mucus/gel-forming	Name2 polypeptide N-acetylgalactosaminyltransferase 14	Pathway 1 Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Pathway 2 O-linked glycosylation of mucins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SPHK1 and RPS6KC1	Name 1 sphingosine kinase 1	Name2 ribosomal protein S6 kinase C1	Pathway 1 Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling PKR-mediated signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SMO and SSPN	Name 1 smoothened, frizzled class receptor	Name2 sarcospan	Pathway 1 Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1 Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib	Drugs 2	Diseases 1 Basal cell carcinoma	Diseases 2
Novel Novel	Symbols TNFSF14 and LHFPL3	Name 1 TNF superfamily member 14	Name2 LHFPL tetraspan subfamily member 3	Pathway 1 TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ADA and ADORA2B	Name 1 adenosine deaminase	Name2 adenosine A2b receptor	Pathway 1 Purine salvage Defective ADA disrupts (deoxy)adenosine deamination Ribavirin ADME	Pathway 2 Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Drugs 1 Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE	Drugs 2 Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883	Diseases 1 T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis	Diseases 2
Novel Novel	Symbols YAP1 and TNRC18	Name 1 Yes1 associated transcriptional regulator	Name2 trinucleotide repeat containing 18	Pathway 1 Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of axial mesoderm Zygotic genome activation (ZGA) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription Developmental Lineage of Pancreatic Ductal Cells	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GTF2F2 and HTATSF1	Name 1 general transcription factor IIF subunit 2	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TCF4 and CFAP77	Name 1 transcription factor 4	Name2 cilia and flagella associated protein 77	Pathway 1 Myogenesis Myogenesis TGFBR3 expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome	Diseases 2
Novel Novel	Symbols ERCC6 and HTATSF1	Name 1 ERCC excision repair 6, chromatin remodeling factor	Name2 HIV-1 Tat specific factor 1	Pathway 1 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1 Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Diseases 2
Novel Novel	Symbols ITPR2 and TRPC4	Name 1 inositol 1,4,5-trisphosphate receptor type 2	Name2 transient receptor potential cation channel subfamily C member 4	Pathway 1 PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Pathway 2 TRP channels Role of second messengers in netrin-1 signaling	Drugs 1 Caffeine	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SF3A2 and HTATSF1	Name 1 splicing factor 3a subunit 2	Name2 HIV-1 Tat specific factor 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CD33 and PTPN11	Name 1 CD33 molecule	Name2 protein tyrosine phosphatase non-receptor type 11	Pathway 1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Pathway 2 Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade Prolactin receptor signaling PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Signaling by Leptin Co-inhibition by CTLA4 Co-inhibition by PD-1 Signal regulatory protein family interactions Netrin mediated repulsion signals Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of IFNG signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Activated NTRK2 signals through FRS2 and FRS3 Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants SARS-CoV-2 activates/modulates innate and adaptive immune responses Co-inhibition by BTLA	Drugs 1 Gemtuzumab ozogamicin AVE9633	Drugs 2 Dodecyltrimethylammonium	Diseases 1	Diseases 2 Metachondromatosis Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Novel Novel	Symbols CCR7 and CCL19	Name 1 C-C motif chemokine receptor 7	Name2 C-C motif chemokine ligand 19	Pathway 1 Chemokine receptors bind chemokines G alpha (i) signalling events	Pathway 2 Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CTSB and CST7	Name 1 cathepsin B	Name2 cystatin F	Pathway 1 Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1	Pathway 2	Drugs 1 2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE	Drugs 2	Diseases 1 Tropical calcific pancreatitis	Diseases 2
Novel	Symbols RNF10 and HTATSF1	Name 1 ring finger protein 10	Name2 HIV-1 Tat specific factor 1	Pathway 1	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RNF10 and NOC3L	Name 1 ring finger protein 10	Name2 NOC3 like DNA replication regulator	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ALK and PTN	Name 1 ALK receptor tyrosine kinase	Name2 pleiotrophin	Pathway 1 Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Pathway 2 Signaling by ALK Signaling by ALK MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Drugs 1 ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib	Drugs 2	Diseases 1 Non-small cell lung cancer	Diseases 2
Novel	Symbols CSF1 and CSF1R	Name 1 colony stimulating factor 1	Name2 colony stimulating factor 1 receptor	Pathway 1 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation Signaling by CSF1 (M-CSF) in myeloid cells Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Other interleukin signaling Transcriptional Regulation by VENTX Signaling by CSF1 (M-CSF) in myeloid cells	Drugs 1	Drugs 2 Imatinib Sunitinib Linifanib 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib	Diseases 1	Diseases 2 Choriocarcinoma
Novel	Symbols APCS and CRP	Name 1 amyloid P component, serum	Name2 C-reactive protein	Pathway 1 Amyloid fiber formation	Pathway 2 Classical antibody-mediated complement activation	Drugs 1 Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate	Drugs 2 N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139	Diseases 1	Diseases 2 Systemic lupus erythematosus
Novel	Symbols CD180 and LY86	Name 1 CD180 molecule	Name2 lymphocyte antigen 86	Pathway 1 Toll Like Receptor 4 (TLR4) Cascade	Pathway 2 Toll Like Receptor 4 (TLR4) Cascade	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MUC5AC and GALNT14	Name 1 mucin 5AC, oligomeric mucus/gel-forming	Name2 polypeptide N-acetylgalactosaminyltransferase 14	Pathway 1 Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Pathway 2 O-linked glycosylation of mucins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SPHK1 and RPS6KC1	Name 1 sphingosine kinase 1	Name2 ribosomal protein S6 kinase C1	Pathway 1 Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling PKR-mediated signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SMO and SSPN	Name 1 smoothened, frizzled class receptor	Name2 sarcospan	Pathway 1 Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1 Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib	Drugs 2	Diseases 1 Basal cell carcinoma	Diseases 2
Novel	Symbols TNFSF14 and LHFPL3	Name 1 TNF superfamily member 14	Name2 LHFPL tetraspan subfamily member 3	Pathway 1 TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ADA and ADORA2B	Name 1 adenosine deaminase	Name2 adenosine A2b receptor	Pathway 1 Purine salvage Defective ADA disrupts (deoxy)adenosine deamination Ribavirin ADME	Pathway 2 Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Drugs 1 Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE	Drugs 2 Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883	Diseases 1 T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis	Diseases 2
Novel	Symbols YAP1 and TNRC18	Name 1 Yes1 associated transcriptional regulator	Name2 trinucleotide repeat containing 18	Pathway 1 Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of axial mesoderm Zygotic genome activation (ZGA) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription Developmental Lineage of Pancreatic Ductal Cells	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GTF2F2 and HTATSF1	Name 1 general transcription factor IIF subunit 2	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TCF4 and CFAP77	Name 1 transcription factor 4	Name2 cilia and flagella associated protein 77	Pathway 1 Myogenesis Myogenesis TGFBR3 expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome	Diseases 2
Novel	Symbols ERCC6 and HTATSF1	Name 1 ERCC excision repair 6, chromatin remodeling factor	Name2 HIV-1 Tat specific factor 1	Pathway 1 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1 Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Diseases 2
Novel	Symbols ITPR2 and TRPC4	Name 1 inositol 1,4,5-trisphosphate receptor type 2	Name2 transient receptor potential cation channel subfamily C member 4	Pathway 1 PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Pathway 2 TRP channels Role of second messengers in netrin-1 signaling	Drugs 1 Caffeine	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SF3A2 and HTATSF1	Name 1 splicing factor 3a subunit 2	Name2 HIV-1 Tat specific factor 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CD33 and PTPN11	Name 1 CD33 molecule	Name2 protein tyrosine phosphatase non-receptor type 11	Pathway 1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Pathway 2 Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade Prolactin receptor signaling PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Signaling by Leptin Co-inhibition by CTLA4 Co-inhibition by PD-1 Signal regulatory protein family interactions Netrin mediated repulsion signals Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of IFNG signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Activated NTRK2 signals through FRS2 and FRS3 Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants SARS-CoV-2 activates/modulates innate and adaptive immune responses Co-inhibition by BTLA	Drugs 1 Gemtuzumab ozogamicin AVE9633	Drugs 2 Dodecyltrimethylammonium	Diseases 1	Diseases 2 Metachondromatosis Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Novel	Symbols CCR7 and CCL19	Name 1 C-C motif chemokine receptor 7	Name2 C-C motif chemokine ligand 19	Pathway 1 Chemokine receptors bind chemokines G alpha (i) signalling events	Pathway 2 Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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