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KIF13B
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kinesin family member 13B |
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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KIFAP3
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kinesin associated protein 3 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- MHC class II antigen presentation
- Intraflagellar transport
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
- Kinesins
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MAP3K3
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mitogen-activated protein kinase kinase kinase 3 |
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MTCL1
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microtubule crosslinking factor 1 |
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NEDD4
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NEDD4 E3 ubiquitin protein ligase |
- ISG15 antiviral mechanism
- Downregulation of ERBB4 signaling
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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NEDD4L
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NEDD4 like E3 ubiquitin protein ligase |
- Budding and maturation of HIV virion
- Downregulation of TGF-beta receptor signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Stimuli-sensing channels
- Antigen processing: Ubiquitination & Proteasome degradation
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PAK5
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p21 (RAC1) activated kinase 5 |
- Activation of RAC1
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RHOD GTPase cycle
- RHOH GTPase cycle
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PARD3B
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par-3 family cell polarity regulator beta |
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PARD6A
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par-6 family cell polarity regulator alpha |
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Tight junction interactions
- Asymmetric localization of PCP proteins
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RHOU GTPase cycle
- RHOV GTPase cycle
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PINK1
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PTEN induced kinase 1 |
- PINK1-PRKN Mediated Mitophagy
- FOXO-mediated transcription of cell death genes
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PKD1
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polycystin 1, transient receptor potential channel interacting |
- VxPx cargo-targeting to cilium
- VxPx cargo-targeting to cilium
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- Polycystic kidney disease
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PRKCE
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protein kinase C epsilon |
- Effects of PIP2 hydrolysis
- SHC1 events in ERBB2 signaling
- DAG and IP3 signaling
- Role of phospholipids in phagocytosis
- G alpha (z) signalling events
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- Tamoxifen
- Staurosporine
- Dequalinium
- KAI-1455
- Benzoyl peroxide
- Bryostatin 1
- Fostamatinib
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PTPRD
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protein tyrosine phosphatase receptor type D |
- Receptor-type tyrosine-protein phosphatases
- Synaptic adhesion-like molecules
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RAB11FIP2
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RAB11 family interacting protein 2 |
- Vasopressin regulates renal water homeostasis via Aquaporins
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RNF41
|
ring finger protein 41 |
- Downregulation of ERBB2:ERBB3 signaling
- Antigen processing: Ubiquitination & Proteasome degradation
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RPA2
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replication protein A2 |
- Translesion synthesis by REV1
- Recognition of DNA damage by PCNA-containing replication complex
- Translesion Synthesis by POLH
- Removal of the Flap Intermediate from the C-strand
- Activation of ATR in response to replication stress
- Regulation of HSF1-mediated heat shock response
- HSF1 activation
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- PCNA-Dependent Long Patch Base Excision Repair
- Translesion synthesis by POLK
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Formation of Incision Complex in GG-NER
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Fanconi Anemia Pathway
- Regulation of TP53 Activity through Phosphorylation
- Activation of the pre-replicative complex
- Removal of the Flap Intermediate
- G2/M DNA damage checkpoint
- Meiotic recombination
- Impaired BRCA2 binding to RAD51
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SMURF1
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SMAD specific E3 ubiquitin protein ligase 1 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Asymmetric localization of PCP proteins
- Hedgehog 'on' state
- Hedgehog 'on' state
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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STK11
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serine/threonine kinase 11 |
- AMPK inhibits chREBP transcriptional activation activity
- Energy dependent regulation of mTOR by LKB1-AMPK
- Regulation of TP53 Activity through Phosphorylation
- FOXO-mediated transcription of cell death genes
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- Peutz-Jeghers syndrome
- Pancreatic cancer
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STK3
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serine/threonine kinase 3 |
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YWHAB
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tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- MTOR signalling
- mTORC1-mediated signalling
- Frs2-mediated activation
- Frs2-mediated activation
- ARMS-mediated activation
- Signaling by Hippo
- Rap1 signalling
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- RAF activation
- MAP2K and MAPK activation
- Negative regulation of MAPK pathway
- Signaling by moderate kinase activity BRAF mutants
- Signaling by high-kinase activity BRAF mutants
- Signaling by BRAF and RAF1 fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Regulation of localization of FOXO transcription factors
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
- SHOC2 M1731 mutant abolishes MRAS complex function
- Gain-of-function MRAS complexes activate RAF signaling
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- SARS-CoV-2 targets host intracellular signalling and regulatory pathways
- Transcriptional and post-translational regulation of MITF-M expression and activity
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- Copper
- Phenethyl Isothiocyanate
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