Search Results for: HOOK1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
HOOK2 hook microtubule tethering protein 2
HOOK3 hook microtubule tethering protein 3
KAT5 lysine acetyltransferase 5
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • DNA Damage/Telomere Stress Induced Senescence
  • HATs acetylate histones
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • Sensing of DNA Double Strand Breaks
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Nonhomologous End-Joining (NHEJ)
  • Homologous DNA Pairing and Strand Exchange
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Estrogen-dependent gene expression
  • Defective homologous recombination repair (HRR) due to BRCA1 loss of function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
  • Impaired BRCA2 binding to RAD51
  • Impaired BRCA2 binding to PALB2
  • Cardiogenesis
  • Coenzyme A
  • S-Acetyl-Cysteine
LENG1 leukocyte receptor cluster member 1
  • mRNA Splicing - Major Pathway
LMO2 LIM domain only 2
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
MEOX2 mesenchyme homeobox 2
PIAS2 protein inhibitor of activated STAT 2
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
PRPF6 pre-mRNA processing factor 6
  • mRNA Splicing - Major Pathway
  • mRNA Splicing - Minor Pathway
RBM22 RNA binding motif protein 22
  • mRNA Splicing - Major Pathway
RNF10 ring finger protein 10
RPS7 ribosomal protein S7
  • L13a-mediated translational silencing of Ceruloplasmin expression
  • Peptide chain elongation
  • SRP-dependent cotranslational protein targeting to membrane
  • SRP-dependent cotranslational protein targeting to membrane
  • Viral mRNA Translation
  • Selenocysteine synthesis
  • rRNA modification in the nucleus and cytosol
  • Major pathway of rRNA processing in the nucleolus and cytosol
  • Translation initiation complex formation
  • Formation of a pool of free 40S subunits
  • Formation of the ternary complex, and subsequently, the 43S complex
  • Ribosomal scanning and start codon recognition
  • GTP hydrolysis and joining of the 60S ribosomal subunit
  • Eukaryotic Translation Termination
  • Regulation of expression of SLITs and ROBOs
  • Response of EIF2AK4 (GCN2) to amino acid deficiency
  • SARS-CoV-1 modulates host translation machinery
  • SARS-CoV-2 modulates host translation machinery
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
  • PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
  • ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
  • Diamond-Blackfan anemia (DBA)
SNW1 SNW domain containing 1
  • Pre-NOTCH Transcription and Translation
  • Pre-NOTCH Transcription and Translation
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
  • NOTCH1 Intracellular Domain Regulates Transcription
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • Notch-HLH transcription pathway
  • mRNA Splicing - Major Pathway
  • RUNX3 regulates NOTCH signaling
  • RUNX3 regulates NOTCH signaling
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH4 Intracellular Domain Regulates Transcription
  • Formation of paraxial mesoderm
TBC1D7 TBC1 domain family member 7
  • TBC/RABGAPs
TFIP11 tuftelin interacting protein 11
  • mRNA Splicing - Major Pathway
UNKL unk like zinc finger
  • Antigen processing: Ubiquitination & Proteasome degradation
USP2 ubiquitin specific peptidase 2
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • TNFR1-induced NF-kappa-B signaling pathway
  • Ub-specific processing proteases
  • Regulation of TP53 Degradation
UTP14A UTP14A small subunit processome component
  • rRNA modification in the nucleus and cytosol
  • Major pathway of rRNA processing in the nucleolus and cytosol
UTP14C UTP14C small subunit processome component
  • rRNA modification in the nucleus and cytosol
  • Major pathway of rRNA processing in the nucleolus and cytosol
VPS16 VPS16 core subunit of CORVET and HOPS complexes
  • SARS-CoV-2 modulates autophagy
VPS18 VPS18 core subunit of CORVET and HOPS complexes
  • SARS-CoV-2 modulates autophagy

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