HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols IFT172 and DNAJC27	Name 1 intraflagellar transport 172	Name2 DnaJ heat shock protein family (Hsp40) member C27	Pathway 1 Hedgehog 'off' state Intraflagellar transport Intraflagellar transport	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TUBA8 and CCT8L2	Name 1 tubulin alpha 8	Name2 chaperonin containing TCP1 subunit 8 like 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Cargo trafficking to the periciliary membrane RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Pathway 2	Drugs 1 Epothilone D Patupilone	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols UNG and KERA	Name 1 uracil DNA glycosylase	Name2 keratocan	Pathway 1	Pathway 2 Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Drugs 1 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid	Drugs 2	Diseases 1 Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3	Diseases 2 Cornea plana congenita
Novel Novel	Symbols FDX1 and CNTN5	Name 1 ferredoxin 1	Name2 contactin 5	Pathway 1 Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1 Mitotane	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATSF1 and THAP1	Name 1 HIV-1 Tat specific factor 1	Name2 THAP domain containing 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NDST1 and ADAM18	Name 1 N-deacetylase and N-sulfotransferase 1	Name2 ADAM metallopeptidase domain 18	Pathway 1 HS-GAG biosynthesis	Pathway 2	Drugs 1 Adenosine 3',5'-diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SORCS3 and ACSM6	Name 1 sortilin related VPS10 domain containing receptor 3	Name2 acyl-CoA synthetase medium chain family member 6	Pathway 1	Pathway 2 Beta oxidation of butanoyl-CoA to acetyl-CoA	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NAT1 and CSMD1	Name 1 N-acetyltransferase 1	Name2 CUB and Sushi multiple domains 1	Pathway 1 Acetylation Paracetamol ADME	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NME8 and SUGCT	Name 1 NME/NM23 family member 8	Name2 succinyl-CoA:glutarate-CoA transferase	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	Diseases 2
Novel Novel	Symbols ARRDC4 and TARS3	Name 1 arrestin domain containing 4	Name2 threonyl-tRNA synthetase 3	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TASP1 and MACROD2	Name 1 taspase 1	Name2 mono-ADP ribosylhydrolase 2	Pathway 1 Formation of WDR5-containing histone-modifying complexes Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TLL2 and HPSE2	Name 1 tolloid like 2	Name2 heparanase 2 (inactive)	Pathway 1 Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Pathway 2 HS-GAG degradation	Drugs 1 Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate	Drugs 2	Diseases 1	Diseases 2 Urofacial syndrome
Novel Novel	Symbols UGT1A3 and AGAP1	Name 1 UDP glucuronosyltransferase family 1 member A3	Name2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	Pathway 1 Glucuronidation NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Aspirin ADME Atorvastatin ADME Prednisone ADME	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols LVRN and DTWD2	Name 1 laeverin	Name2 DTW motif tRNA-uridine aminocarboxypropyltransferase 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CNTN6 and CNTN4	Name 1 contactin 6	Name2 contactin 4	Pathway 1 CHL1 interactions	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NCBP1 and NCBP2	Name 1 nuclear cap binding protein subunit 1	Name2 nuclear cap binding protein subunit 2	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay	Pathway 2 SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NUP93 and NUP205	Name 1 nucleoporin 93	Name2 nucleoporin 205	Pathway 1 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FLNC and SGCD	Name 1 filamin C	Name2 sarcoglycan delta	Pathway 1 Cell-extracellular matrix interactions	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1	Drugs 2	Diseases 1 Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Diseases 2 Dilated cardiomyopathy (DCM) Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
Novel Novel	Symbols FLNC and RPS6KA2	Name 1 filamin C	Name2 ribosomal protein S6 kinase A2	Pathway 1 Cell-extracellular matrix interactions	Pathway 2 ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Drugs 1	Drugs 2	Diseases 1 Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Diseases 2
Novel Novel	Symbols FLNC and XIRP2	Name 1 filamin C	Name2 xin actin binding repeat containing 2	Pathway 1 Cell-extracellular matrix interactions	Pathway 2 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Drugs 1	Drugs 2	Diseases 1 Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Diseases 2
Novel	Symbols IFT172 and DNAJC27	Name 1 intraflagellar transport 172	Name2 DnaJ heat shock protein family (Hsp40) member C27	Pathway 1 Hedgehog 'off' state Intraflagellar transport Intraflagellar transport	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TUBA8 and CCT8L2	Name 1 tubulin alpha 8	Name2 chaperonin containing TCP1 subunit 8 like 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Cargo trafficking to the periciliary membrane RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Pathway 2	Drugs 1 Epothilone D Patupilone	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols UNG and KERA	Name 1 uracil DNA glycosylase	Name2 keratocan	Pathway 1	Pathway 2 Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Drugs 1 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid	Drugs 2	Diseases 1 Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3	Diseases 2 Cornea plana congenita
Novel	Symbols FDX1 and CNTN5	Name 1 ferredoxin 1	Name2 contactin 5	Pathway 1 Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1 Mitotane	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATSF1 and THAP1	Name 1 HIV-1 Tat specific factor 1	Name2 THAP domain containing 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NDST1 and ADAM18	Name 1 N-deacetylase and N-sulfotransferase 1	Name2 ADAM metallopeptidase domain 18	Pathway 1 HS-GAG biosynthesis	Pathway 2	Drugs 1 Adenosine 3',5'-diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SORCS3 and ACSM6	Name 1 sortilin related VPS10 domain containing receptor 3	Name2 acyl-CoA synthetase medium chain family member 6	Pathway 1	Pathway 2 Beta oxidation of butanoyl-CoA to acetyl-CoA	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NAT1 and CSMD1	Name 1 N-acetyltransferase 1	Name2 CUB and Sushi multiple domains 1	Pathway 1 Acetylation Paracetamol ADME	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NME8 and SUGCT	Name 1 NME/NM23 family member 8	Name2 succinyl-CoA:glutarate-CoA transferase	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	Diseases 2
Novel	Symbols ARRDC4 and TARS3	Name 1 arrestin domain containing 4	Name2 threonyl-tRNA synthetase 3	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TASP1 and MACROD2	Name 1 taspase 1	Name2 mono-ADP ribosylhydrolase 2	Pathway 1 Formation of WDR5-containing histone-modifying complexes Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TLL2 and HPSE2	Name 1 tolloid like 2	Name2 heparanase 2 (inactive)	Pathway 1 Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Pathway 2 HS-GAG degradation	Drugs 1 Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate	Drugs 2	Diseases 1	Diseases 2 Urofacial syndrome
Novel	Symbols UGT1A3 and AGAP1	Name 1 UDP glucuronosyltransferase family 1 member A3	Name2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	Pathway 1 Glucuronidation NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Aspirin ADME Atorvastatin ADME Prednisone ADME	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols LVRN and DTWD2	Name 1 laeverin	Name2 DTW motif tRNA-uridine aminocarboxypropyltransferase 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CNTN6 and CNTN4	Name 1 contactin 6	Name2 contactin 4	Pathway 1 CHL1 interactions	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NCBP1 and NCBP2	Name 1 nuclear cap binding protein subunit 1	Name2 nuclear cap binding protein subunit 2	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay	Pathway 2 SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NUP93 and NUP205	Name 1 nucleoporin 93	Name2 nucleoporin 205	Pathway 1 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FLNC and SGCD	Name 1 filamin C	Name2 sarcoglycan delta	Pathway 1 Cell-extracellular matrix interactions	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1	Drugs 2	Diseases 1 Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Diseases 2 Dilated cardiomyopathy (DCM) Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
Novel	Symbols FLNC and RPS6KA2	Name 1 filamin C	Name2 ribosomal protein S6 kinase A2	Pathway 1 Cell-extracellular matrix interactions	Pathway 2 ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Drugs 1	Drugs 2	Diseases 1 Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Diseases 2
Novel	Symbols FLNC and XIRP2	Name 1 filamin C	Name2 xin actin binding repeat containing 2	Pathway 1 Cell-extracellular matrix interactions	Pathway 2 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Drugs 1	Drugs 2	Diseases 1 Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Diseases 2

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