IFT172 and DNAJC27

		IFT172	DNAJC27
Description		intraflagellar transport 172	DnaJ heat shock protein family (Hsp40) member C27
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GO Annotations	Cellular Component	Cilium Axoneme Intraciliary Transport Particle Intraciliary Transport Particle B Ciliary Basal Body Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip Sperm Cytoplasmic Droplet Extracellular Vesicle	Nucleus Organelle Membrane Cytoplasmic Vesicle
	Molecular Function		Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Neural Tube Formation Neural Tube Closure Heart Looping Notch Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Brain Development Heart Development Epidermis Development Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Negative Regulation Of Keratinocyte Proliferation Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Development Cytoplasmic Microtubule Organization Intraciliary Anterograde Transport Intraciliary Transport Keratinocyte Proliferation Cilium Organization Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Limb Development Cilium Assembly Bone Development Hindgut Development Left/right Axis Specification Non-motile Cilium Assembly	Intracellular Protein Transport Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Calcium levels ( 20705733) Chronic kidney disease ( 20383146) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Total cholesterol levels ( 30718733)	Appendicular lean mass ( 33097823) Body mass index ( 22344219 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 20881960 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obese vs. thin ( 30677029) Obesity (extreme) ( 30677029) Pre-treatment viral load in HIV-1 infection ( 31219150) Pubertal anthropometrics ( 23449627) Type 1 diabetes ( 21980299)
Interacting Genes		3 interacting genes: LCOR LHX3 LHX4
Entrez ID		26160	51277
HPRD ID		09576	15221
Ensembl ID		ENSG00000138002	ENSG00000115137
Uniprot IDs		A0A6Q8PGJ2 Q9UG01	Q9NZQ0
PDB IDs		9H2D	2YS8
Enriched GO Terms of Interacting Partners?		Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Cell Differentiation In Spinal Cord Placenta Development Ventral Spinal Cord Interneuron Specification Prolactin Secreting Cell Differentiation Somatotropin Secreting Cell Differentiation Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Thyroid-stimulating Hormone-secreting Cell Differentiation Protein Localization To Plasma Membrane Insulin-responsive Compartment Spinal Cord Motor Neuron Cell Fate Specification Neuron Projection Guidance Axon Guidance Protein Localization To Cell Periphery Secretory Vesicle	Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Hindgut Development Sperm Cytoplasmic Droplet Intraciliary Transport Particle Insulin-responsive Compartment Cilium Secretory Vesicle Neural Tube Formation Cadherin Binding Involved In Cell-cell Adhesion Endoplasmic Reticulum Tubular Network Organization Exocytic Vesicle Myosin V Binding Exocyst Endoplasmic Reticulum Tubular Network Polarized Epithelial Cell Differentiation Embryonic Epithelial Tube Formation Left/right Axis Specification Negative Regulation Of Keratinocyte Proliferation Intraciliary Transport Particle B Embryonic Eye Morphogenesis Embryonic Camera-type Eye Morphogenesis Spinal Cord Motor Neuron Differentiation Intraciliary Anterograde Transport Sperm Principal Piece Keratinocyte Proliferation Golgi To Plasma Membrane Protein Transport Cell Projection Organization Establishment Of Protein Localization To Endoplasmic Reticulum Epithelial Tube Formation Negative Regulation Of Smoothened Signaling Pathway Cell Differentiation In Spinal Cord Positive Regulation Of Smoothened Signaling Pathway Intracellular Transport Neural Tube Development Cell Projection Ciliary Tip Regulation Of Keratinocyte Proliferation Intraciliary Transport Sperm Midpiece Non-motile Cilium Assembly Digestive Tract Development Limb Development Endoplasmic Reticulum Organization Cellular Localization Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Of Localization In Cell Golgi To Plasma Membrane Transport
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