HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols KPNA2 and RANBP2	Name 1 karyopherin subunit alpha 2	Name2 RAN binding protein 2	Pathway 1 CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols KPNA2 and NUP62	Name 1 karyopherin subunit alpha 2	Name2 nucleoporin 62	Pathway 1 CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols KPNA2 and RNMT	Name 1 karyopherin subunit alpha 2	Name2 RNA guanine-7 methyltransferase	Pathway 1 CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols DAXX and CDCA7L	Name 1 death domain associated protein	Name2 cell division cycle associated 7 like	Pathway 1 SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols DAXX and CEP63	Name 1 death domain associated protein	Name2 centrosomal protein 63	Pathway 1 SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Pathway 2 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GRIK1 and PTPRD	Name 1 glutamate ionotropic receptor kainate type subunit 1	Name2 protein tyrosine phosphatase receptor type D	Pathway 1 Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Pathway 2 Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	Drugs 1 Glutamic acid Butabarbital Topiramate Tezampanel	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GRIK1 and HOMER1	Name 1 glutamate ionotropic receptor kainate type subunit 1	Name2 homer scaffold protein 1	Pathway 1 Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Pathway 2 Neurexins and neuroligins Neurexins and neuroligins	Drugs 1 Glutamic acid Butabarbital Topiramate Tezampanel	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CCNT1 and GRN	Name 1 cyclin T1	Name2 granulin precursor	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Pathway 2 Neutrophil degranulation	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Novel Novel	Symbols CCNT1 and CDK9	Name 1 cyclin T1	Name2 cyclin dependent kinase 9	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Drugs 1	Drugs 2 Alvocidib Seliciclib Trilaciclib Zotiraciclib	Diseases 1	Diseases 2
Novel Novel	Symbols CCNT1 and HTATSF1	Name 1 cyclin T1	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GNAZ and RAP1GAP	Name 1 G protein subunit alpha z	Name2 RAP1 GTPase activating protein	Pathway 1 G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Pathway 2 Rap1 signalling RET signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GNAZ and NMT1	Name 1 G protein subunit alpha z	Name2 N-myristoyltransferase 1	Pathway 1 G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Pathway 2 Late Phase of HIV Life Cycle eNOS activation Inactivation, recovery and regulation of the phototransduction cascade Activation, myristolyation of BID and translocation to mitochondria	Drugs 1	Drugs 2 (1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone	Diseases 1	Diseases 2
Novel Novel	Symbols GNAO1 and GPSM2	Name 1 G protein subunit alpha o1	Name2 G protein signaling modulator 2	Pathway 1 Ca2+ pathway Ca2+ pathway	Pathway 2 G alpha (i) signalling events	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PRRC2A and RBFOX1	Name 1 proline rich coiled-coil 2A	Name2 RNA binding fox-1 homolog 1	Pathway 1	Pathway 2 MECP2 regulates transcription factors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CCR10 and CCL25	Name 1 C-C motif chemokine receptor 10	Name2 C-C motif chemokine ligand 25	Pathway 1 Chemokine receptors bind chemokines G alpha (i) signalling events	Pathway 2 Chemokine receptors bind chemokines G alpha (i) signalling events	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PSMA3 and LINC00908	Name 1 proteasome 20S subunit alpha 3	Name2 long intergenic non-protein coding RNA 908	Pathway 1 Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2	Drugs 1 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols QARS1 and VPS37B	Name 1 glutaminyl-tRNA synthetase 1	Name2 VPS37B subunit of ESCRT-I	Pathway 1 Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols QARS1 and NEBL	Name 1 glutaminyl-tRNA synthetase 1	Name2 nebulette	Pathway 1 Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols QARS1 and SORBS3	Name 1 glutaminyl-tRNA synthetase 1	Name2 sorbin and SH3 domain containing 3	Pathway 1 Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Smooth Muscle Contraction	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTT and TAF4	Name 1 huntingtin	Name2 TATA-box binding protein associated factor 4	Pathway 1 Regulation of MECP2 expression and activity	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1 Copper	Drugs 2	Diseases 1 Huntington's disease (HD)	Diseases 2
Novel	Symbols KPNA2 and RANBP2	Name 1 karyopherin subunit alpha 2	Name2 RAN binding protein 2	Pathway 1 CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols KPNA2 and NUP62	Name 1 karyopherin subunit alpha 2	Name2 nucleoporin 62	Pathway 1 CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols KPNA2 and RNMT	Name 1 karyopherin subunit alpha 2	Name2 RNA guanine-7 methyltransferase	Pathway 1 CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Pathway 2 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols DAXX and CDCA7L	Name 1 death domain associated protein	Name2 cell division cycle associated 7 like	Pathway 1 SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols DAXX and CEP63	Name 1 death domain associated protein	Name2 centrosomal protein 63	Pathway 1 SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Pathway 2 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GRIK1 and PTPRD	Name 1 glutamate ionotropic receptor kainate type subunit 1	Name2 protein tyrosine phosphatase receptor type D	Pathway 1 Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Pathway 2 Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	Drugs 1 Glutamic acid Butabarbital Topiramate Tezampanel	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GRIK1 and HOMER1	Name 1 glutamate ionotropic receptor kainate type subunit 1	Name2 homer scaffold protein 1	Pathway 1 Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Pathway 2 Neurexins and neuroligins Neurexins and neuroligins	Drugs 1 Glutamic acid Butabarbital Topiramate Tezampanel	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CCNT1 and GRN	Name 1 cyclin T1	Name2 granulin precursor	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Pathway 2 Neutrophil degranulation	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Novel	Symbols CCNT1 and CDK9	Name 1 cyclin T1	Name2 cyclin dependent kinase 9	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Drugs 1	Drugs 2 Alvocidib Seliciclib Trilaciclib Zotiraciclib	Diseases 1	Diseases 2
Novel	Symbols CCNT1 and HTATSF1	Name 1 cyclin T1	Name2 HIV-1 Tat specific factor 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GNAZ and RAP1GAP	Name 1 G protein subunit alpha z	Name2 RAP1 GTPase activating protein	Pathway 1 G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Pathway 2 Rap1 signalling RET signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GNAZ and NMT1	Name 1 G protein subunit alpha z	Name2 N-myristoyltransferase 1	Pathway 1 G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Pathway 2 Late Phase of HIV Life Cycle eNOS activation Inactivation, recovery and regulation of the phototransduction cascade Activation, myristolyation of BID and translocation to mitochondria	Drugs 1	Drugs 2 (1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone	Diseases 1	Diseases 2
Novel	Symbols GNAO1 and GPSM2	Name 1 G protein subunit alpha o1	Name2 G protein signaling modulator 2	Pathway 1 Ca2+ pathway Ca2+ pathway	Pathway 2 G alpha (i) signalling events	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PRRC2A and RBFOX1	Name 1 proline rich coiled-coil 2A	Name2 RNA binding fox-1 homolog 1	Pathway 1	Pathway 2 MECP2 regulates transcription factors	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CCR10 and CCL25	Name 1 C-C motif chemokine receptor 10	Name2 C-C motif chemokine ligand 25	Pathway 1 Chemokine receptors bind chemokines G alpha (i) signalling events	Pathway 2 Chemokine receptors bind chemokines G alpha (i) signalling events	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PSMA3 and LINC00908	Name 1 proteasome 20S subunit alpha 3	Name2 long intergenic non-protein coding RNA 908	Pathway 1 Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2	Drugs 1 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols QARS1 and VPS37B	Name 1 glutaminyl-tRNA synthetase 1	Name2 VPS37B subunit of ESCRT-I	Pathway 1 Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols QARS1 and NEBL	Name 1 glutaminyl-tRNA synthetase 1	Name2 nebulette	Pathway 1 Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols QARS1 and SORBS3	Name 1 glutaminyl-tRNA synthetase 1	Name2 sorbin and SH3 domain containing 3	Pathway 1 Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Smooth Muscle Contraction	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTT and TAF4	Name 1 huntingtin	Name2 TATA-box binding protein associated factor 4	Pathway 1 Regulation of MECP2 expression and activity	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1 Copper	Drugs 2	Diseases 1 Huntington's disease (HD)	Diseases 2

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