PRRC2B - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	AK8	adenylate kinase 8	Interconversion of nucleotide di- and triphosphates	Bis(Adenosine)-5'-Pentaphosphate
Novel	CFAP77	cilia and flagella associated protein 77
Novel	DDX31	DEAD-box helicase 31
Novel	GTF3C4	general transcription factor IIIC subunit 4	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Novel	PLPP7	phospholipid phosphatase 7 (inactive)
Novel	SETX	senataxin			Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)
Novel	UCK1	uridine-cytidine kinase 1	Pyrimidine salvage
	ALG13	ALG13 UDP-N-acetylglucosaminyltransferase subunit	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes ALG14-CMS
	ANKHD1	ankyrin repeat and KH domain containing 1
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Gantenerumab Aducanumab Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form Lecanemab	Alzheimer's disease (AD)
	ATN1	atrophin 1	Regulation of PTEN gene transcription		Dentatorubropallidoluysian atrophy (DRPLA)
	ATXN1	ataxin 1			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
	ATXN1L	ataxin 1 like
	BAG4	BAG cochaperone 4	Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
	BCAS2	BCAS2 pre-mRNA processing factor	mRNA Splicing - Major Pathway
	CRK	CRK proto-oncogene, adaptor protein	ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis
	CTBP1	C-terminal binding protein 1	Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Formic acid
	DAPK1	death associated protein kinase 1	Caspase activation via Dependence Receptors in the absence of ligand	5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE Fostamatinib	Bladder cancer
	DDX11	DEAD/H-box helicase 11	XBP1(S) activates chaperone genes		Warsaw breakage syndrome
	DIMT1	DIM1 rRNA methyltransferase and ribosome maturation factor	rRNA modification in the nucleus and cytosol

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