NR4A3 and SMOC1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NR4A3	SMOC1
Name		nuclear receptor subfamily 4 group A member 3	SPARC related modular calcium binding 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Extracellular Region Basement Membrane Extracellular Space
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Heparin Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Axon Guidance Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of D-glucose Transmembrane Transport Hippocampus Development Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Adult Behavior Positive Regulation Of Mast Cell Cytokine Production Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Response To Hydrogen Peroxide Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Neuromuscular Process Controlling Balance Neuron Apoptotic Process Vestibular Reflex Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Dendritic Cell Apoptotic Process Positive Regulation Of Monocyte Aggregation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior Positive Regulation Of Dendritic Cell Apoptotic Process	Eye Development Cell Differentiation Extracellular Matrix Organization Regulation Of Osteoblast Differentiation Limb Development
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	None
Drugs		Dasatinib	None
Diseases		Extraskeletal myxoid chondrosarcoma	None
GWAS		Dental caries ( 23064961 ) Depression in smokers ( 30219690 ) Eosinophil percentage of white cells ( 32888494 ) Lung cancer ( 28604730 ) Systemic lupus erythematosus ( 33536424 ) Type 1 diabetes ( 34127860 )	Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Bone mineral density ( 24249740 ) Daytime sleep phenotypes ( 27126917 ) Digit length ratio ( 29659830 ) Digit length ratio (left hand) ( 29659830 ) Digit length ratio (right hand) ( 29659830 ) Heel bone mineral density ( 30598549 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912 ) Peripheral artery disease ( 31285632 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 ) Triglyceride levels ( 30108155 ) Tuberculosis ( 24057671 )
Interacting Genes		43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330	10 interacting genes: CYSRT1 KRTAP1-1 KRTAP10-3 KRTAP10-8 NOTCH2NLA NR4A3 SMOC2 TCF4 TNC VGLL3
Entrez ID		8013	64093
HPRD ID		02766	12244
Ensembl ID		ENSG00000119508	ENSG00000198732
Uniprot IDs		Q92570	Q9H4F8
PDB IDs		8XTT	Not available
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Embryo Implantation	Keratin Filament