CENPH and ERH

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CENPH	ERH
Name		centromere protein H	ERH mRNA splicing and mitosis factor
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Nucleus Midbody Methylosome
	Molecular Function	Protein Binding Kinetochore Binding	RNA Binding Protein Binding Methyl-CpG Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Kinetochore Assembly Kinetochore Organization	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleoside Metabolic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	None
GWAS		No GWAS studies recorded	Lymphocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 )
Interacting Genes		19 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 CRYAA DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NUF2 NUP54 RASSF4 SPAG5 UBC ZNF493 ZSCAN12	26 interacting genes: APP ATP6V0C CENPH CIZ1 COPS6 CSNK2A1 CSNK2A2 CTDP1 CYSRT1 FNDC3B HSPA8 IFITM10 IGSF21 MED31 POLDIP3 PSMA6 RBM48 RPS6KA5 SETDB1 SH3GL2 TASOR2 TLE1 TP53 UNC119 UPRT WEE2-AS1
Entrez ID		64946	2079
HPRD ID		12029	09026
Ensembl ID		ENSG00000153044	ENSG00000100632
Uniprot IDs		A0A0S2Z5T0 Q9H3R5	P84090
PDB IDs		7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	1W9G 2NML 7CNC 7X39
GO Terms Enriched among Interactors		Lens Fiber Cell Morphogenesis Kinetochore Nuclear Chromosome Segregation Cytoskeleton Organization Protein Localization To Nuclear Envelope Microtubule Cytoskeleton Organization Nucleus Organization Microtubule-based Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Microtubule Plus-end Chromosome Segregation Organelle Organization Spindle Organization Chromosome, Centromeric Region Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Cell Morphogenesis Nucleoside Metabolic Process Midbody S-methyl-5-thioadenosine Phosphorylase Activity Mitotic Metaphase Chromosome Alignment Protein Localization To Cytoskeleton Organelle Localization Structural Constituent Of Nuclear Lamina Nicotinamide Riboside Catabolic Process Zonula Adherens Assembly Metaphase Chromosome Alignment Regulation Of Cellular Localization Microtubule Binding Establishment Of Organelle Localization Protein Localization To Nuclear Inner Membrane	Regulation Of Protein Import Nucleoplasm Protein Kinase CK2 Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macroautophagy Protein Targeting To Vacuole Involved In Autophagy