CENPH and C8orf58

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CENPH	C8orf58
Description		centromere protein H	chromosome 8 open reading frame 58
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol
	Molecular Function	Protein Binding Kinetochore Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Kinetochore Assembly Kinetochore Organization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Parkinson's disease ( 28892059) Triglycerides ( 30275531)
Interacting Genes		19 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 CRYAA DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NUF2 NUP54 RASSF4 SPAG5 UBC ZNF493 ZSCAN12	1 interacting genes: CENPH
Entrez ID		64946	541565
HPRD ID		12029	18675
Ensembl ID		ENSG00000153044	ENSG00000241852
Uniprot IDs		A0A0S2Z5T0 Q9H3R5	A0A087WX44 Q8NAV2
PDB IDs		7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Lens Fiber Cell Morphogenesis Kinetochore Nuclear Chromosome Segregation Cytoskeleton Organization Protein Localization To Nuclear Envelope Microtubule Cytoskeleton Organization Nucleus Organization Microtubule-based Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Microtubule Plus-end Chromosome Segregation Organelle Organization Spindle Organization Chromosome, Centromeric Region Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Cell Morphogenesis Nucleoside Metabolic Process Midbody S-methyl-5-thioadenosine Phosphorylase Activity Mitotic Metaphase Chromosome Alignment Protein Localization To Cytoskeleton Organelle Localization Structural Constituent Of Nuclear Lamina Nicotinamide Riboside Catabolic Process Zonula Adherens Assembly Metaphase Chromosome Alignment Regulation Of Cellular Localization Microtubule Binding Establishment Of Organelle Localization Protein Localization To Nuclear Inner Membrane	Kinetochore Binding Kinetochore Organization Kinetochore Assembly Inner Kinetochore Chromosome Segregation Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis Chromosome, Centromeric Region Mitotic Spindle Organization Kinetochore Membraneless Organelle Assembly
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