HLA-DQA1 and HLA-DQB1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology, affinity chromatography technology)

		HLA-DQA1	HLA-DQB1
Description		major histocompatibility complex, class II, DQ alpha 1	major histocompatibility complex, class II, DQ beta 1
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Humoral Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs
Diseases		Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Dilated cardiomyopathy (DCM) Type I diabetes mellitus	Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Asthma Dilated cardiomyopathy (DCM) Viral myocarditis Tuberculosis Type I diabetes mellitus
GWAS		A body shape index ( 34021172) Adult asthma ( 30578877) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-polyomavirus 2 IgG seropositivity ( 33204752) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Apolipoprotein B levels ( 32203549) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542) Aspartate aminotransferase levels ( 33339817 33547301) Asthma ( 23181788 27182965 29273806 30929738 31361310 31619474 31959851 32296059 34103634) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basal cell carcinoma ( 31174203 33549134) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Celiac disease ( 17558408 20190752) Cervical cancer ( 23482656 28806749) Cervical intraepithelial neoplasia grade 3 ( 33794208) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Childhood asthma with severe exacerbations ( 33328473) Childhood ear infection ( 27182965 28928442) Childhood steroid-sensitive nephrotic syndrome ( 29903748 31263063) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 21131588) Chronic obstructive pulmonary disease ( 33909500) Chronic rhinosinusitis ( 30643255) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Creatinine levels ( 29403010) Crohn's disease ( 23266558 23850713 26891255) Cutaneous lupus erythematosus ( 25827949) Cutaneous squamous cell carcinoma ( 32041948) Drug-induced liver injury (flucloxacillin) ( 30661239) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein Barr virus nuclear antigen 1 IgG seropositivity ( 29868224) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Epstein-Barr virus immune response (multivariate analysis) ( 29868224) Epstein-Barr virus VCA p18 antibody levels ( 33204752) Epstein-Barr virus ZEBRA antibody levels ( 33204752) Estimated glomerular filtration rate ( 30604766) Factor VIII levels ( 30586737) Giant cell arteritis ( 25817017 28041642) Glomerular filtration rate ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Human herpes virus 6 IE1A antibody levels ( 33204752) Human herpes virus 7 U14 antibody levels ( 33204752) Hypothyroidism ( 22493691 27182965) Idiopathic membranous nephropathy ( 21323541) IgA nephropathy ( 25305756 26028593) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A vasculitis ( 28698626) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 18758464 28008999 28067908) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Leprosy ( 32421744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 31577861) Lymphocyte count ( 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Lymphoma ( 23349640) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Membranous nephropathy ( 27333618) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Monocyte percentage of white cells ( 32888494) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nasal polyps ( 30643255) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neuromyelitis optica ( 29769526 32792643) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Oligoclonal band status in multiple sclerosis ( 25616667) Oropharynx cancer ( 32276964) Parental lifespan ( 29030599 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 27182965 28892059) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 23918589) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 19571809 23212062) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Shingles ( 28928442) Sjögren's syndrome ( 24097066 24097067 28076899) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 26829030 31174203) Squamous cell lung carcinoma ( 28604730) Strep throat ( 28928442) Systemic lupus erythematosus ( 18204098 21408207 24871463 26316170 26606652 32771030) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549) Tuberculosis ( 28928442) Type 1 diabetes (age at diagnosis) ( 33179336) Type 2 diabetes ( 28566273) Ulcerative colitis ( 19122664 21297633 23128233 23511034 24837172 26278503 28008999 28067908) Urate levels ( 31578528) Varicella zoster virus glycoproteins E and I antibody levels ( 33204752) Vitiligo ( 20410501 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	A body shape index ( 34021172) Acute-on-chronic liver failure in hepatitis B ( 28130311) Addison's disease ( 33574239) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 25608926) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 30053915) Anti-varicella zoster virus IgG seropositivity ( 33204752) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542) Asthma ( 21804548 30929738 31361310 31619474 31959851 34103634) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Bullous pemphigoid ( 34011352) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cataracts (operation) ( 31816047) CCL19 levels ( 25147954) Celiac disease ( 20190752) Cervical cancer ( 28806749) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Childhood ear infection ( 28928442) Childhood steroid-sensitive nephrotic syndrome ( 29903748 31263063) Chronic hepatitis B infection ( 25802187) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 26956414) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 23266558 26891255 30500874) Diastolic blood pressure ( 27618447) Drug-induced liver injury (flucloxacillin) ( 30661239) Eczema ( 31361310) Emphysema imaging phenotypes ( 26030696) Enteric fever ( 25383971) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus immune response (EBNA-1) ( 23326239) FEV1 ( 30804560) Follicular lymphoma ( 20639881 21533074) Frailty index ( 34431594) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 32203549) Head and neck squamous cell carcinoma ( 32276964) Height ( 31562340) Helicobacter pylori OMP antibody levels ( 33204752) Hepatitis B ( 21750111 28928442) Hepatitis C (spontaneous viral clearance) ( 30593799) Hepatocellular carcinoma in hepatitis C infection ( 28921602) High altitude adaptation ( 28373541) Hip circumference adjusted for BMI ( 34021172) HPV seropositivity ( 21896673) Hypothyroidism ( 22493691 27182965) IgA nephropathy ( 25305756 26028593) IgE levels ( 23146381) IgG levels ( 28628107) Immunoglobulin A vasculitis ( 28698626) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kawasaki disease ( 33106546) Knee osteoarthritis ( 20305777) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 1 diabetes ( 30254083) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 33339817) Lung cancer in ever smokers ( 28604730) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Lymphoma ( 23349640) Mean corpuscular volume ( 32888494) Medication use (antihistamines for systemic use) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Mitochondrial heteroplasmy measurement ( 33731350) Moderate to vigorous physical activity levels ( 29899525) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840) Multiple sclerosis (OCB status) ( 23472185) Myositis ( 26291516) Nephropathy ( 21399633) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 22086417) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 32276964) Oropharynx cancer ( 27749845) Parkinson's disease ( 31660654) Peak expiratory flow ( 30804560) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 19458352 20639880) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 29403010) Response to hepatitis B vaccine ( 29534301) Rheumatic heart disease ( 32488134) Rheumatoid arthritis ( 23918589 24782177) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 30285260) Self-reported allergy ( 23817569) Sero-negative rheumatoid arthritis ( 28706201) Serum IgE levels ( 25488688) Serum uric acid levels ( 30993211) Severe autoimmune type 2 diabetes ( 34737425) Shingles ( 28928442) Sjögren's syndrome ( 24097067 28076899) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26316170 26502338 26606652) Systemic sclerosis ( 20383147 21779181) Takayasu arteritis ( 23830517) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Tonsillectomy ( 28928442) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Tuberculosis ( 28928442 29036319) Type 1 diabetes ( 31152121) Type 1 diabetes (age at diagnosis) ( 33179336) Type 2 diabetes ( 30054458) Ulcerative colitis ( 19122664 23128233 24837172 28067908) Urate levels ( 31985003) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494) Yeast infection ( 28928442)
Interacting Genes		9 interacting genes: APLP1 CD74 CDK7 HLA-DQB1 IKBKG LRIF1 SH3GL2 TLE1 UNC119	5 interacting genes: CD4 CD74 HLA-DQA1 HLA-DQA2 INS
Entrez ID		3117	3119
HPRD ID		06765	05054
Ensembl ID		ENSG00000196735	ENSG00000179344
Uniprot IDs		A0A173ADG5 A0A346FLH4 A0A649ZVH5 L8E864 P01909 Q5Y7C6 Q5Y7H0 Q8MH44	P01920 Q5SU54 Q5Y7A9 Q5Y7D3 Q5Y7D6
PDB IDs		1JK8 1S9V 1UVQ 2NNA 3PL6 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KS9 5KSA 5KSB 5KSU 5KSV 6MFF 6MFG 6U3M 6U3N 6XP6 7SG0 7SG1 7SG2 8VSP 8W83 8W84 8W85 8W86	1JK8 1S9V 1UVQ 2NNA 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KSU 5KSV 6DIG 6XP6 7KEI 7SG1 7SG2 8VSP
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex Clathrin-coated Endocytic Vesicle Membrane MHC Class II Protein Complex Binding Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Endocytic Vesicle Membrane Antigen Processing And Presentation Trans-Golgi Network Membrane Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Peptide Antigen Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion MHC Class II Receptor Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Immune Response Adaptive Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Golgi Membrane Regulation Of Cell Activation Lysosomal Membrane Antigen Receptor-mediated Signaling Pathway Late Endosome Membrane Endosome Protein-containing Complex Assembly Regulation Of Cell Adhesion Lysosome Alpha-2B Adrenergic Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Protein-containing Complex Organization NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway	MHC Class II Protein Complex Binding Clathrin-coated Endocytic Vesicle Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of T Cell Activation Transport Vesicle Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion ER To Golgi Transport Vesicle Membrane Adaptive Immune Response Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Endocytic Vesicle Membrane MHC Class II Protein Binding Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Processing And Presentation MHC Class II Receptor Activity Trans-Golgi Network Membrane Positive Regulation Of Monocyte Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Viral Entry Into Host Cell Regulation Of Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of Multicellular Organismal Process Golgi Membrane Regulation Of Cell Activation Regulation Of Monocyte Differentiation Positive Regulation Of Immune Response Regulation Of Viral Entry Into Host Cell Immune System Process Positive Regulation Of Viral Life Cycle Regulation Of Cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction T Cell Selection Peptide Antigen Binding T Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Canonical NF-kappaB Signal Transduction
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