GRP and GRPR

Number of citations: 0 (PubMedID 12021405)
Data Source: BioGRID (unspecified method), HPRD (in vivo)

		GRP	GRPR
Name		gastrin releasing peptide	gastrin releasing peptide receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection	Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding	G Protein-coupled Receptor Activity Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Neuropeptide Binding
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway Social Behavior Psychomotor Behavior Response To External Biotic Stimulus Mast Cell Degranulation Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Behavioral Fear Response	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Learning Or Memory Social Behavior Psychomotor Behavior Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Motor Behavior Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Behavioral Fear Response
Pathways		Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
GWAS		Adult body size ( 32376654 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 25673413 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Medication use (drugs used in diabetes) ( 31015401 ) Pancreas volume ( 34128465 ) Pancreatic cancer ( 26098869 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883 ) Type 2 diabetes ( 30297969 ) Venous thromboembolism ( 32232851 )	Lung function (FEV1/FVC) ( 26635082 )
Interacting Genes		5 interacting genes: ALX1 DPP4 GRPR MEP1A MEP1B	1 interacting genes: GRP
Entrez ID		2922	2925
HPRD ID		08845	02376
Ensembl ID		ENSG00000134443	ENSG00000126010
Uniprot IDs		A0A140VJM7 P07492	P30550 X5D7H2
PDB IDs		2N0B 2N0C 2N0D 2N0E 2N0F 2N0G 2N0H 7W3Z 8H0Q	7W3Z 7W40 7W41 8H0Q
GO Terms Enriched among Interactors		Meprin A Complex Psychomotor Behavior Motor Behavior Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Glucagon Processing Metalloendopeptidase Activity Epidermal Growth Factor Receptor Ligand Maturation Metallopeptidase Activity Hormone Metabolic Process Protein Processing Positive Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Neutrophil Chemotaxis Intercellular Canaliculus Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Positive Regulation Of Behavioral Fear Response Mesenchymal Cell Development Positive Regulation Of Fear Response Metallodipeptidase Activity Protein Maturation Negative Regulation Of Extracellular Matrix Disassembly Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Cell-cell Adhesion Mediated By Integrin Dipeptidyl-peptidase Activity Virion Attachment To Host Cell Proteolysis Regulation Of Behavioral Fear Response Adhesion Of Symbiont To Host Endocytosis Involved In Viral Entry Into Host Cell Locomotory Exploration Behavior Neuropeptide Receptor Activity Negative Regulation Of Extracellular Matrix Organization Lamellipodium Membrane Negative Regulation Of Leukocyte Chemotaxis Regulation Of Extracellular Matrix Disassembly Hydrolase Activity Chemorepellent Activity Regulation Of Respiratory Gaseous Exchange Neuropeptide Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Behavior	Positive Regulation Of Behavioral Fear Response Positive Regulation Of Fear Response Positive Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Psychomotor Behavior Regulation Of Behavioral Fear Response Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Nervous System Process Neuropeptide Hormone Activity Positive Regulation Of Behavior Motor Behavior Regulation Of Respiratory Gaseous Exchange Mast Cell Degranulation Leukocyte Degranulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Lysosome Localization Social Behavior Regulation Of Behavior Neuropeptide Signaling Pathway Regulated Exocytosis Regulation Of Nervous System Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Secretory Granule Lumen Positive Regulation Of Hormone Secretion Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Exocytosis Regulation Of Hormone Secretion Establishment Of Organelle Localization Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Neuron Projection