CDK20 and PPP5C

Number of citations: 69 (PubMedID 16954377)
Data Source: BioGRID (pull down)

		CDK20	PPP5C
Name		cyclin dependent kinase 20	protein phosphatase 5 catalytic subunit
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cilium Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex Neuronal Cell Body Perikaryon Protein Folding Chaperone Complex Proximal Dendrite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	G-protein Alpha-subunit Binding RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Hydrolase Activity Phosphatase Activity Protein Serine/threonine Kinase Inhibitor Activity Hsp70 Protein Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding ADP Binding Protein-containing Complex Binding Metal Ion Binding Tau Protein Binding Hsp90 Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Smoothened Signaling Pathway Floor Plate Formation Embryonic Camera-type Eye Development Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Development Cell Division Regulation Of Cell Cycle Roof Of Mouth Development Protein Localization To Cilium Regulation Of Protein Maturation Embryonic Brain Development	MAPK Cascade Mitotic Cell Cycle DNA Repair Double-strand Break Repair DNA-templated Transcription DNA Damage Response Response To Lead Ion Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Negative Regulation Of MAPK Cascade Peptidyl-serine Dephosphorylation Cellular Response To Hydrogen Peroxide Cellular Response To Cadmium Ion Response To Arachidonate Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways		None	Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling
Drugs		None	ATP
GWAS		No GWAS studies recorded	Basophil percentage of white cells ( 27863252 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Hemoglobin ( 32888494 ) Lymphocyte count ( 32888494 ) Neuroticism ( 29255261 ) Response to antidepressants in depression ( 29998114 ) Triglyceride levels ( 32203549 )
Interacting Genes		9 interacting genes: CCNH CDK2 CILK1 CSNK2B GTF2IRD1 GTF2IRD2 PANK4 PPP5C TRIM2	30 interacting genes: APP BRWD1 CDC16 CDC27 CDC37 CDK20 CEBPA CHORDC1 CPNE1 CPNE2 CPNE4 CRY2 CSE1L CSNK1D DISC1 EGFR ESR2 GNA12 GNA13 HSP90AA1 HTR2A HUWE1 MAP3K5 MAP3K7 MAPT OGT PPP2R1A PPP2R3A SIM2 VHL
Entrez ID		23552	5536
HPRD ID		13010	02805
Ensembl ID		ENSG00000156345	ENSG00000011485
Uniprot IDs		A0A0S2Z562 A0A0S2Z5B6 Q8IZL9	P53041
PDB IDs		Not available	1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69 4ZVZ 4ZX2 5HPE 5UI1 5WG8 7ZR5 7ZR6 8GAE 8GFT
GO Terms Enriched among Interactors		Phosphate-containing Compound Metabolic Process Phosphorylation Protein Phosphorylation DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Protein Modification Process Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Male Germ Cell Nucleus ATP Binding Brain-derived Neurotrophic Factor Receptor Activity Transition Between Slow And Fast Fiber Macromolecule Metabolic Process Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphatase Activity Pantothenate Kinase Activity Transcription Factor TFIIK Complex Positive Regulation Of Chromatin Organization Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Brain-derived Neurotrophic Factor Binding Response To Arachidonate Peptidyl-serine Dephosphorylation CAK-ERCC2 Complex X Chromosome Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Receptor Activity Trans-synaptic Signaling By BDNF Neurotrophin Binding Protein Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Release From Viral Latency Pantothenate Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Protection From Non-homologous End Joining At Telomere	Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication D5 Dopamine Receptor Binding Neurofibrillary Tangle Assembly Protein Branched Polyubiquitination Circadian Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Binding MAP Kinase Kinase Kinase Activity Protein Localization To Organelle Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Metabolic Process Response To Metal Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphatase Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Main Axon Kinase Binding Regulation Of Gene Expression Regulation Of Proteolysis Rho-activating G Protein-coupled Receptor Signaling Pathway Hsp90 Protein Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Memory Regulation Of Cell Cycle Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Circadian Rhythm Protein Localization To Cytoskeleton Positive Regulation Of Cell Differentiation