MAST1 and RNLS

Number of citations: 58 (PubMedID 21163940)
Data Source: BioGRID (two hybrid)

		MAST1	RNLS
Name		microtubule associated serine/threonine kinase 1	renalase, FAD dependent amine oxidase
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Epinephrine Binding NADH Binding Monoamine Oxidase Activity
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Brain Development Developmental Process Intracellular Signal Transduction	Response To Ischemia Negative Regulation Of Heart Rate Negative Regulation Of Blood Pressure Response To Catecholamine Response To Epinephrine Response To Salt
Pathways		None	Nicotinate metabolism
Drugs		Fostamatinib	None
GWAS		High light scatter reticulocyte count ( 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Red blood cell count ( 29403010 ) Reticulocyte fraction of red cells ( 32888494 )	Alanine aminotransferase levels ( 33547301 ) Birth weight ( 31043758 ) Cortical amyloid beta load ( 29860282 ) Depressive and manic episodes in bipolar disorder ( 26297903 ) End stage renal disease in APOL1 risk genotype-negative individuals ( 29885931 ) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046 ) Familial lung adenocarcinoma ( 29924316 ) Height ( 31562340 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Mercury levels ( 26025379 ) Pancreas volume ( 34128465 ) Prostate cancer ( 29892016 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thyroid stimulating hormone levels ( 32769997 ) Type 1 diabetes ( 30572963 30659077 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		41 interacting genes: A2M ACE2 AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 TIAM1 VANGL2	2 interacting genes: FAM107A MAST1
Entrez ID		22983	55328
HPRD ID		17469	07742
Ensembl ID		ENSG00000105613	ENSG00000184719
Uniprot IDs		Q9Y2H9	B4DJW3 Q5VYX0
PDB IDs		2M9X 3PS4	3QJ4
GO Terms Enriched among Interactors		Lipoprotein Particle Acetylcholine Receptor Activator Activity Negative Regulation Of Smooth Muscle Cell Proliferation Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Amyloid Fibril Formation Chemical Synaptic Transmission Catabolic Process Cytosol Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Trans-synaptic Signaling Oxidative Demethylation Synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Oxidoreductase Activity Arachidonate Epoxygenase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Wound Healing Negative Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Blood Circulation Demethylation Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Axonogenesis Epoxygenase P450 Pathway Low-density Lipoprotein Particle Removal Of Superoxide Radicals Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Dystrophin-associated Glycoprotein Complex Regulation Of Hemostasis Heparan Sulfate Proteoglycan Binding Intracellular Signaling Cassette Regulation Of Amyloid Fibril Formation Regulation Of Response To Wounding Negative Regulation Of Platelet Activation Cognition Cellular Oxidant Detoxification Regulation Of Transport Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance	None