DIS3L and RNF20

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		DIS3L	RNF20
Name		DIS3 like exosome 3'-5' exoribonuclease	ring finger protein 20
Structure
GO Annotations	Cellular Component	Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding Nuclease Activity Exonuclease Activity RNA Nuclease Activity Protein Binding Exoribonuclease II Activity Hydrolase Activity Enzyme Binding	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity
	Biological Process	RNA Processing RNA Catabolic Process MRNA Catabolic Process Gene Expression RRNA Catabolic Process	Protein Polyubiquitination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Cell Migration Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		None	E3 ubiquitin ligases ubiquitinate target proteins RHOBTB1 GTPase cycle
GWAS		Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: BTG3 DSCR9 HUNK PAXIP1 RNF20	41 interacting genes: AIRIM AMOTL2 ATM BAG4 CDC73 DIS3L EEF1D FBH1 FGFR4 H2AC18 H2AC20 H2AC4 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 NCBP1 PA2G4 PAF1 PRPF8 RAD51 RB1CC1 RBPMS RPA1 RPA2 SUMO2 TACC3 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17
Entrez ID		115752	56254
HPRD ID		11355	07410
Ensembl ID		ENSG00000166938	ENSG00000155827
Uniprot IDs		Q8TF46	Q5VTR2
PDB IDs		9G8M 9G8N 9G8O 9G8P	5TRB 8GUI 8GUJ 8IEJ
GO Terms Enriched among Interactors		None	Structural Constituent Of Chromatin Chromosome, Telomeric Region Nucleus Nucleosome Ubiquitin Conjugating Enzyme Activity Nucleoplasm Chromosome Chromatin Organization Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Protein Heterodimerization Activity Chromatin Remodeling DNA Repair Telomere Maintenance Protein Localization To Chromosome PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Double-strand Break Repair Chromosome Organization DNA Recombination Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Cellular Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Cycle Process DNA Metabolic Process Protein Polyubiquitination DNA Binding Positive Regulation Of MRNA 3'-end Processing HULC Complex Nuclear Division MRNA 3'-end Processing DNA Damage Response Endodermal Cell Fate Commitment Protein-DNA Complex Assembly Site Of Double-strand Break Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of DNA Metabolic Process Post-translational Protein Modification Meiotic Telomere Clustering