DYRK1B

Name	dual specificity tyrosine phosphorylation regulated kinase 1B
Structure
Interactors	12 interactors: DCAF7 GSC2 HDAC5 ID2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Repair Protein Phosphorylation DNA Damage Response Myoblast Fusion Positive Regulation Of DNA-templated Transcription Adipose Tissue Development
Drugs	Fostamatinib
GWAS	Macular thickness ( 30535121 )
Entrez ID	9149
HPRD ID	05188
Ensembl ID	ENSG00000105204
Uniprot IDs	A0A9H4CVU7 Q9Y463
PDB IDs	8C2Z
GO Terms Enriched among Interactors ?	MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Muscle Cell Differentiation Cellular Senescence NLRP1 Inflammasome Complex Assembly Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Cellular Response To UV-B MAP Kinase Activity MAP Kinase Kinase Activity Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Molecule Of Bacterial Origin Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Response To UV-B Stress-activated MAPK Cascade Protein-containing Complex Negative Regulation Of Hippo Signaling P38MAPK Cascade Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Insulin Nucleoplasm Cellular Response To Lipopolysaccharide Astrocyte Differentiation Canonical Inflammasome Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Erythrocyte Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Endothelial Cell Migration Cytosol Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Striated Muscle Cell Differentiation Pyroptotic Inflammatory Response Regulation Of Cell Motility Regulation Of Hippo Signaling Regulation Of Myotube Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Erythrocyte Differentiation Positive Regulation Of Locomotion Positive Regulation Of Metabolic Process Kinase Activity Positive Regulation Of Metalloendopeptidase Activity Heart Development