KSR1

Name	kinase suppressor of ras 1
Structure
Interactors	10 interactors: BRAP EPHB2 ITCH MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 YWHAZ
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade
Pathways	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
GWAS	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Systemic lupus erythematosus ( 28714469 )
Entrez ID	8844
HPRD ID	18980
Ensembl ID	ENSG00000141068
Uniprot IDs	A0A2R8Y5H9 Q8IVT5
PDB IDs	5VYK 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1 9AXH
GO Terms Enriched among Interactors ?	Transferase Activity Regulation Of MAPK Cascade ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway MAPK Cascade Schwann Cell Development Protein Modification Process Face Development ERBB2 Signaling Pathway Kinase Activity Thyroid Gland Development Protein Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Golgi Inheritance Negative Regulation Of Signal Transduction Thymus Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity Glial Cell Development Trachea Formation ERBB Signaling Pathway Intracellular Signal Transduction Gland Development Bergmann Glial Cell Differentiation Myelination Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Protein Metabolic Process Early Endosome Protein Serine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Golgi Organization Pseudopodium ATP Binding Regulation Of Early Endosome To Late Endosome Transport Type B Pancreatic Cell Proliferation Regulation Of Defense Response Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Animal Organ Formation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Macromolecule Metabolic Process